Mathematical models in population genetics, such as diffusion approximations and mutation-selection-drift equations, successfully characterize the evolutionary dynamics and loss of alleles in populations.
The claim is specific, empirical, and testable within population genetics. Multiple papers retrieved (such as papers 0, 1, 2, and 10) explicitly discuss and utilize mathematical formulas and models to describe the loss, fixation, and maintenance of genes and alleles in populations. There is no evidence refuting the core claim.