Maintaining ketosis over an extended period is safe for the human body
the verdict
SUPPORTED
the evidence backs this
confidence 94/100
Evidence from clinical reviews, guidelines, and long-term trials indicates that maintaining ketosis through ketogenic diets is generally safe and well-tolerated for extended periods.
Evidence for · 4
Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets
2013 · cited by 901
Paper 1 discusses the safety and therapeutic applications of ketogenic diets over extended periods, noting their use since the 1920s.
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More for · 3
Very-low-carbohydrate ketogenic diet <i>v.</i> low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials
2013 · cited by 781
Paper 2 demonstrates in a meta-analysis that very-low-carbohydrate ketogenic diets are safe and effective for long-term weight loss and cardiovascular risk management over 12 months or more.
Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group
2008 · cited by 608
Paper 4 outlines clinical management guidelines for patients, including children, safely maintaining ketogenic diets for long-term epilepsy management.
Ketogenic diet in the treatment of cancer – Where do we stand?
2019 · cited by 473
Paper 5 highlights the overall good safety, tolerability, and clinical potential of the ketogenic diet when used as an adjuvant therapy.