Acid reflux and GERD cause chest pain due to esophageal spasms and mucosal irritation
the verdict
SUPPORTED
the evidence backs this
confidence 89/100
Evidence indicates that gastroesophageal reflux disease is a leading cause of noncardiac chest pain, driven by mechanisms such as mucosal irritation from acid exposure and underlying esophageal dysmotility or spasms.
Evidence for · 3
Noncardiac Chest Pain: Epidemiology, Natural Course and Pathogenesis
2011 · cited by 187
Identifies gastroesophageal reflux as a primary underlying mechanism and the most common cause of noncardiac chest pain, alongside esophageal dysmotility and hypersensitivity.
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More for · 2
Non-cardiac chest pain: a 2018 update.
2018 · cited by 15
Notes that GERD is the most common contributing factor for non-cardiac chest pain, with spastic motility disorders and visceral hypersensitivity driving symptoms.
Capsaicin-Sensitive Vagal Afferent Nerve-Mediated Interoceptive Signals in the Esophagus
2021 · cited by 13
Discusses how noxious chemical and mechanical stimuli, such as acid from GERD, activate esophageal vagal afferent nerves to induce nociception and chest pain.