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the claim

Individuals with complete androgen insensitivity syndrome and a 46,XY karyotype can get pregnant

the verdict
REFUTED
the evidence says no
Recorded sources
0 sources for · 3 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that individuals with complete androgen insensitivity syndrome and a 46,XY karyotype can get pregnant?

No. Individuals with complete androgen insensitivity syndrome and a 46,XY karyotype have female external genitalia and normal breast development, but they lack a uterus and fallopian tubes, resulting in primary amenorrhea and complete infertility.

Verdict: REFUTED · 0 sources for, 3 against · Last checked

The analysis

The claim states that individuals with complete androgen insensitivity syndrome (CAIS) and a 46,XY karyotype can get pregnant. Papers [5], [7], and [10] all explicitly state that CAIS is characterized by the absence of a uterus and fallopian tubes (due to the action of anti-Müllerian hormone and lack of functional internal female structures), resulting in primary amenorrhea and infertility. No retrieved papers support the claim that individuals with CAIS can get pregnant (while paper [11] discusses pregnancy in Swyer syndrome—which involves functional uteri and donor eggs—Swyer syndrome is pure gonadal dysgenesis, not CAIS, and CAIS lacks a uterus entirely). Therefore, the claim is definitively refuted by the consensus of medical literature on CAIS.

Evidence against · 3
2024
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Yu, T. & Liu, L. (2024). Pure 46, XY gonadal dysgenesis and 46, XY complete androgen insensitivity syndrome: A case report. doi.org. https://doi.org/10.1097/MD.0000000000038297

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More against · 2
2025
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C, W. & Q, T. (2025). Molecular pathogenesis, diagnosis, and management challenges in complete androgen insensitivity syndrome.. doi.org. https://doi.org/10.3389/fendo.2025.1600343

2022
Get citation
Grądzik, A., Gorajek, A., Kudan, M., Osiejewska, A., & Mikut, K. (2022). 46 XY, Female. Complete androgen insensitivity syndrome: a case report. doi.org. https://doi.org/10.12775/jehs.2022.12.07.088

Receipt History
first checked05 Aug 2026
judged → REFUTED · 405 Aug 2026
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