Individuals with complete androgen insensitivity syndrome and a 46,XY karyotype can get pregnant
Is it true that individuals with complete androgen insensitivity syndrome and a 46,XY karyotype can get pregnant?
No. Individuals with complete androgen insensitivity syndrome and a 46,XY karyotype have female external genitalia and normal breast development, but they lack a uterus and fallopian tubes, resulting in primary amenorrhea and complete infertility.
Verdict: REFUTED · 0 sources for, 3 against · Last checked
The claim states that individuals with complete androgen insensitivity syndrome (CAIS) and a 46,XY karyotype can get pregnant. Papers [5], [7], and [10] all explicitly state that CAIS is characterized by the absence of a uterus and fallopian tubes (due to the action of anti-Müllerian hormone and lack of functional internal female structures), resulting in primary amenorrhea and infertility. No retrieved papers support the claim that individuals with CAIS can get pregnant (while paper [11] discusses pregnancy in Swyer syndrome—which involves functional uteri and donor eggs—Swyer syndrome is pure gonadal dysgenesis, not CAIS, and CAIS lacks a uterus entirely). Therefore, the claim is definitively refuted by the consensus of medical literature on CAIS.
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Yu, T. & Liu, L. (2024). Pure 46, XY gonadal dysgenesis and 46, XY complete androgen insensitivity syndrome: A case report. doi.org. https://doi.org/10.1097/MD.0000000000038297
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C, W. & Q, T. (2025). Molecular pathogenesis, diagnosis, and management challenges in complete androgen insensitivity syndrome.. doi.org. https://doi.org/10.3389/fendo.2025.1600343
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Grądzik, A., Gorajek, A., Kudan, M., Osiejewska, A., & Mikut, K. (2022). 46 XY, Female. Complete androgen insensitivity syndrome: a case report. doi.org. https://doi.org/10.12775/jehs.2022.12.07.088
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