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the claim
Glyceryl trinitrate patches cause severe headaches as a side effect
the verdict
COMMON KNOWLEDGE
no citation needed for this one
refutedsupported
the weight of evidence
no sources on either side

The occurrence of headaches as a side effect of glyceryl trinitrate (nitroglycerin) is a well-known, direct physiological consequence of its vasodilatory action and is considered common knowledge requiring no citation.

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The analysis

The claim states that glyceryl trinitrate patches cause severe headaches as a side effect. Vasodilation caused by nitric oxide donors frequently triggers headaches (in fact, nitroglycerin is widely used experimentally to induce migraine-like headaches in animal models, as seen in papers [2], [3], [5], [7], and [9]). This is a textbook medical fact about organic nitrates known by everyday clinical observation and pharmacology. Following the instructions for STEP 0, trivial or well-established direct observations of this nature are classified as COMMON_KNOWLEDGE, meaning no papers should be attached and no formal evidence weigh-in is necessary.

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first checked04 Aug 2026
judged → COMMON KNOWLEDGE · 9504 Aug 2026
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