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the claim
Enzyme-substrate quantum tunneling reactions require macroscopic physical considerations for spatial positioning
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
4 sources for · 0 against

Enzyme-substrate quantum tunneling reactions are strongly dependent on macroscopic physical considerations, such as protein conformational dynamics and spatial positioning, which modulate barrier widths and distances to facilitate tunneling.

Evidence for · 4
Hydrogen Tunneling Links Protein Dynamics to Enzyme Catalysis
2013 · cited by 356
Demonstrates that thermodynamically equilibrated protein motions control H-donor and -acceptor distances to create conformational ensembles suitable for quantum tunneling.
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The analysis

The retrieved papers consistently support the premise that quantum tunneling in enzymatic reactions is inextricably linked to protein conformational dynamics, structural ensembles, and the precise spatial positioning of donor and acceptor atoms. Papers [0], [1], [3], and [5] emphasize that macroscopic protein motions, active-site electrostatics, and distance gating are essential for establishing the conformational states necessary for hydrogen tunneling. No papers refute the claim.

More for · 3
Enzyme activation by urea reveals the interplay between conformational dynamics and substrate binding: a single-molecule FRET study
2024 · cited by 1
Shows that enzyme conformational dynamics and urea-induced structural changes directly regulate substrate positioning and catalytic efficacy.
New Insight into Quantum Mechanical Hydrogen Tunneling in Enzymes.
2026 · cited by 0
Highlights how protein dynamics, vibrational gating, and electrostatics modulate barrier width to sustain tunneling-derived rate enhancements.
Quantum mechanics/molecular mechanics studies of triosephosphate isomerase-catalyzed reactions: effect of geometry and tunneling on proton-transfer rate constants.
2002 · cited by 0
Indicates that local atomic motions, such as donor-acceptor vibrations within active sites, directly determine the magnitude of quantum tunneling.
Everything we examined (11)
  1. Hydrogen Tunneling Links Protein Dynamics to Enzyme Catalysispeer-reviewedsupports
  2. Enzyme activation by urea reveals the interplay between conformational dynamics and substrate binding: a single-molecule FRET studypeer-reviewedsupports
  3. Simulations of conformational changes and enzyme-substrate interactions in protein drug targetspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. New Insight into Quantum Mechanical Hydrogen Tunneling in Enzymes.peer-reviewedsupports
  5. Hydrogen tunneling in biology.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. Quantum mechanics/molecular mechanics studies of triosephosphate isomerase-catalyzed reactions: effect of geometry and tunneling on proton-transfer rate constants.peer-reviewedsupports
  7. Reaction mechanism of the bicopper enzyme peptidylglycine α-hydroxylating monooxygenase.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. Unraveling the role of protein dynamics in dihydrofolate reductase catalysis.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. How important are quantum mechanical effects in controlling biological functions: Enzymes, electron transfer and bird navigation.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Ab Initio QM/MM Modeling of the Rate-Limiting Proton Transfer Step in the Deamination of Tryptamine by Aromatic Amine Dehydrogenase.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Analysis of classical and quantum paths for deprotonation of methylamine by methylamine dehydrogenase.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → SUPPORTED · 9105 Aug 2026
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