Children previously treated for leukaemia or malignant tumours may experience neuro-psychologic disturbances, bone deformities, decreased reproductive capacity, and second tumours as late effects of therapy.
Is it true that children previously treated for leukaemia or malignant tumours may experience neuro-psychologic disturbances, bone deformities, decreased reproductive capacity, and second tumours as late effects of therapy?
Yes. Children previously treated for cancer frequently experience long-term complications, including neuro-psychological disturbances, skeletal abnormalities, and other chronic late effects of therapy.
Verdict: SUPPORTED · 6 sources for, 0 against · Last checked
The claim specifies that pediatric cancer survivors face various late effects, such as neuro-psychological disturbances, bone deformities, decreased reproductive capacity, and second tumours. The retrieved literature extensively corroborates that survivors face profound long-term physical, cognitive, endocrine, skeletal, and oncological sequelae due to aggressive multi-modal therapies. Therefore, the evidence clearly supports the claim.
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AI, C., G, K., S, T., & F, B. (2025). Neurocognitive and Emotional Outcomes in Childhood Cancer: A Developmental Perspective.. doi.org. https://doi.org/10.3390/curroncol32110611
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LM, J., RK, P., KA, O., A, S., DJ, M., & K, E. (2025). Neuropsychological function in childhood cancer patients and adult survivors of childhood cancer.. doi.org. https://doi.org/10.1080/13803395.2025.2521018
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Z, D., T, S., A, B., K, K., A, K., & I, F. (2026). Optimizing the Efficacy-Toxicity Paradigm in Pediatric Oncology: A Narrative Review of Immunotherapy and Survivorship Outcomes.. doi.org. https://doi.org/10.3390/curroncol33050298
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E, F., V, C., B, G., LF, S., & TK, S. (2025). Pediatric Cancer Survivorship: A Review.. doi.org. https://doi.org/10.3928/19382359-20250909-03
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A, W., M, C., S, S., O, C., P, L., & K, D. (2026). Head and Neck Rhabdomyosarcoma in Children: An Otolaryngological Perspective on Diagnostic and Therapeutic Approaches.. doi.org. https://doi.org/10.1007/s11912-026-01823-1
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H, F., S, H., R, S., Y, Y., M, I., K, N., A, M., K, M., T, S., M, M., H, S., & H, T. (2026). Burden of disease-specific late effects after proton beam therapy in pediatric solid and CNS tumor survivors: a single-institution survey in Japan.. doi.org. https://doi.org/10.1093/jjco/hyag081
What does the evidence say?
The claim specifies that pediatric cancer survivors face various late effects, such as neuro-psychological disturbances, bone deformities, decreased reproductive capacity, and second tumours. The retrieved literature extensively corroborates that survivors face profound long-term physical, cognitive, endocrine, skeletal, and oncological sequelae due to aggressive multi-modal therapies. Therefore, the evidence clearly supports the claim.
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