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the claim

Trazodone HCL use is associated with the risk of priapism.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Trazodone HCL use is associated with the risk of priapism?

Yes. Trazodone use is well-documented in clinical literature and case reports to be associated with a rare but serious risk of priapism, largely attributed to its alpha-1 adrenergic blocking properties.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked

The analysis

The retrieved literature contains multiple specific clinical references and case reports linking trazodone to priapism, spanning from early reports in the 1980s to recent 2026 guides. There are no papers refuting this well-established pharmaceutical adverse effect.

Evidence for · 4
Trazodone Guide: Pharmacology, Indications, Dosing Guidelines and Adverse Effects
2026
A 2026 clinical guide on trazodone specifically highlights the need to evaluate priapism risk factors in male patients.
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Malleza, S. (2026). Trazodone Guide: Pharmacology, Indications, Dosing Guidelines and Adverse Effects. doi.org. https://doi.org/10.64239/pi-bg019

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More for · 3
Citalopram-induced priapism.
2002
A 2002 case report notes a patient history of priapism associated with trazodone use.
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Dent, L. A., Brown, W. C., & Murney, J. D. (2002). Citalopram-induced priapism.. doi.org. https://doi.org/10.1592/phco.22.7.538.33672

[Trazodone-induced priapism].
2000
A 2000 case study details a patient experiencing prolonged priapism while being treated with trazodone for depression.
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Gómez, M. A. C., Martín, J. A. P., García, B. M., Rodríguez, R. H., Baños, J. L. G., Schaan, J. I. d. V., Edreira, A. R., Velázquez, M. A. R., & Castrillo, A. H. (2000). [Trazodone-induced priapism].. doi.org. https://doi.org/10.1016/s0210-4806(00)72559-9

Trazodone and priapism.
1983
Early literature from 1983 documents multiple clinical cases of priapism linked to the introduction of trazodone.
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Scher, M., Krieger, J. N., & Juergens, S. (1983). Trazodone and priapism.. doi.org. https://doi.org/10.1176/ajp.140.10.1362

What does the evidence say?

The retrieved literature contains multiple specific clinical references and case reports linking trazodone to priapism, spanning from early reports in the 1980s to recent 2026 guides. There are no papers refuting this well-established pharmaceutical adverse effect.

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