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the claim
TRALI is a major cause of mortality in individuals receiving plasma-containing transfusions.
the verdict
SUPPORTED
the evidence backs this
Recorded sources
6 sources for · 0 against
Is it true that TRALI is a major cause of mortality in individuals receiving plasma-containing transfusions?
Yes. Transfusion-related acute lung injury (TRALI) is widely recognized in the medical literature as a leading and major cause of mortality associated with blood and plasma-containing transfusions.
Verdict: SUPPORTED · 6 sources for, 0 against · Last checked
The analysis
Multiple comprehensive reviews and clinical studies confirm that TRALI is a primary cause of mortality in blood transfusion recipients.
Evidence for · 6
States that TRALI is the major cause of transfusion-related morbidity and mortality worldwide.
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Fung, Y. & Silliman, C. (2009). The Role of Neutrophils in the Pathogenesis of Transfusion-Related Acute Lung Injury (TRALI). doi.org. https://doi.org/10.1016/j.tmrv.2009.06.001
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More for · 5
Identifies TRALI as a primary and potentially lethal cause of transfusion-related mortality.
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Fang, X., Mo, C., Zheng, L., Gao, F., Xue, F., & Zheng, X. (2025). Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies. doi.org. https://doi.org/10.1002/advs.202413364
Notes that TRALI is the most common cause of death from blood transfusion, including cases linked to plasma-containing products like red blood cells.
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Weber, L. L., Roberts, L. D., & Sweeney, J. D. (2014). Residual plasma in red blood cells and transfusion‐related acute lung injury. doi.org. https://doi.org/10.1111/trf.12662
Affirms that TRALI remains one of the most serious complications of blood transfusion, contributing to significant mortality worldwide.
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Kuriri, F. A. (2025). Transfusion-related acute lung injury (TRALI). doi.org. https://doi.org/10.15537/smj.2025.46.8.20250233
Notes that TRALI is a life-threatening complication of blood transfusion with very high mortality rates in critically ill patients.
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Rayatdoost, F. & Kapur, R. (2025). Transfusion-related acute lung injury: experimental models to study pathogenesis and therapeutic strategies.. doi.org. https://doi.org/10.1016/j.coi.2025.102650
Recognizes TRALI as a leading cause of transfusion-associated morbidity and mortality.
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A, M., S, S., N, S., H, M., & A, A. (2026). Concurrent transfusion-related acute lung injury and posterior reversible encephalopathy: A rare multisystem imaging presentation.. doi.org. https://doi.org/10.1016/j.radcr.2026.07.098
What does the evidence say?
Multiple comprehensive reviews and clinical studies confirm that TRALI is a primary cause of mortality in blood transfusion recipients.
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