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the claim

Topoisomerases relieve the supercoiling that builds up ahead of the replication fork during DNA replication.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
9 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Topoisomerases relieve the supercoiling that builds up ahead of the replication fork during DNA replication?

Yes. Multiple peer-reviewed sources state that DNA unwinding during replication builds positive supercoils ahead of the fork and that topoisomerases relieve this topological strain. A review and a PNAS paper directly describe topoisomerases removing the superhelical strain at the elongating fork.

Verdict: SUPPORTED · 9 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 9
Semiconservative replication
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Semiconservative replication. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Semiconservative_replication

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More for · 8
How Topoisomerases Relax and Disentangle the Genome During DNA Replication
2026
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Dewar, J. (2026). How Topoisomerases Relax and Disentangle the Genome During DNA Replication. doi.org. https://doi.org/10.2139/ssrn.6732681

Condensin and topoisomerases cooperate to relieve topological stress at stalled replication forks
2025
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Condensin and topoisomerases cooperate to relieve topological stress at stalled replication forks. (2025). hal.science. https://doi.org/10.1101/2025.08.06.668895

Replication Fork Barriers and Topological Barriers: Progression of DNA Replication Relies on DNA Topology Ahead of Forks
2020
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Schvartzman, J. B., Hernández, P., & Krimer, D. B. (2020). Replication Fork Barriers and Topological Barriers: Progression of DNA Replication Relies on DNA Topology Ahead of Forks. doi.org. https://doi.org/10.1002/bies.201900204

Chromatin Architectural Factors as Safeguards against Excessive Supercoiling during DNA Replication
2020
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Ahmed, S. M. & Dröge, P. (2020). Chromatin Architectural Factors as Safeguards against Excessive Supercoiling during DNA Replication. doi.org. https://doi.org/10.3390/ijms21124504

Decatenation activity of topoisomerase IV during oriC and pBR322 DNA replication in vitro.
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Decatenation activity of topoisomerase IV during oriC and pBR322 DNA replication in vitro.. (n.d.). cir.nii.ac.jp. https://doi.org/10.1073/pnas.90.18.8571

Topological challenges to DNA replication: Conformations at the fork
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Topological challenges to DNA replication: Conformations at the fork. (n.d.). cir.nii.ac.jp. https://doi.org/10.1073/pnas.111006998

Simulating the Relaxation of DNA Supercoils By Topoisomerase I
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Simulating the Relaxation of DNA Supercoils By Topoisomerase I. (n.d.). cir.nii.ac.jp. https://doi.org/10.1016/j.bpj.2009.12.417

Inhibition of topoisomerase 2 catalytic activity impacts the integrity of heterochromatin and repetitive DNA and leads to interlinks between clustered repeats
2024
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Inhibition of topoisomerase 2 catalytic activity impacts the integrity of heterochromatin and repetitive DNA and leads to interlinks between clustered repeats. (2024). hal.science. https://doi.org/10.1038/s41467-024-49816-7

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