There are chiral compounds that do not rotate plane-polarized light
the verdict
SUPPORTED
the evidence backs this
confidence 82/100
Certain chiral molecules, known as cryptochiral compounds, exhibit such extremely weak or near-zero optical rotation that standard chiroptical methods fail, requiring specialized amplification techniques to detect their optical activity.
Evidence for · 3
Discrimination of cryptochirality in chiral isotactic polystyrene by asymmetric autocatalysis.
2009 · cited by 14
Discusses cryptochiral polystyrenes, which possess chirality but exhibit extremely weak optical rotation.
See more details
More for · 2
Chiroptical Sensing of Amino Acid Derivatives by Host-Guest Complexation with Cyclo[6]aramide.
2021 · cited by 7
Notes that certain chiral amino acid derivatives are cryptochiral molecules with negligible optical rotation requiring specialized amplification.
A stereodynamic probe of Pt(II) molecular hinge for chiroptical sensing of cryptochiral compounds.
2025 · cited by 2
Focuses on cryptochiral compounds, which have chiral structures but present severe challenges for standard optical rotation detection.