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The number and type of cells carrying a somatic mutation in an organism depend on when and where the mutation occurs.

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SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that the number and type of cells carrying a somatic mutation in an organism depend on when and where the mutation occurs?

Yes. Evidence from modern genetic and developmental studies confirms that the distribution, frequency, and consequences of somatic mutations in an organism are fundamentally shaped by when (developmental timing) and where (tissue type and cellular layer) they occur.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

Evidence for · 3
Spatial variation in the mutation rate within the plant shoot apical meristem.
2025
Demonstrates that plant mutation rates and accumulation patterns vary significantly depending on layer and tissue context, reflecting developmental timing and cellular position.
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KR, A., MPA, M., O, N., K, S., IJ, D., A, P., IM, H., & L, C. (2025). Spatial variation in the mutation rate within the plant shoot apical meristem.. doi.org. https://doi.org/10.1073/pnas.2514507122

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More for · 2
Focal Cortical Dysplasia Type II: Somatic Mutations, Molecular Mechanisms, and Integrative Multi-Omics Framework.
2026
Shows that the developmental timing, lineage distribution, and local expansion of somatic variants directly dictate lesion extent and phenotypic heterogeneity in mosaic disorders.
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Z, L., Y, W., J, S., Y, L., Y, S., & G, Z. (2026). Focal Cortical Dysplasia Type II: Somatic Mutations, Molecular Mechanisms, and Integrative Multi-Omics Framework.. doi.org. https://doi.org/10.1002/cns.71170

Reconstructing developmental lineages: a retrospective approach using somatic mutations and variant allele frequency.
2025
Explains that the characteristics and frequency of somatic mutations are contingent on developmental timing and tissue type, leading to distinct somatic mosaicism.
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M, S. & SG, K. (2025). Reconstructing developmental lineages: a retrospective approach using somatic mutations and variant allele frequency.. doi.org. https://doi.org/10.3389/fgene.2025.1761810

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