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the claim

The normal concentration of calcium ions in the cytosol of a cell is approximately 100 nM.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

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Is it true that the normal concentration of calcium ions in the cytosol of a cell is approximately 100 nM?

Yes. The claim that the normal resting concentration of calcium ions in the cytosol is approximately 100 nM is well-supported by physiological studies demonstrating typical baseline intracellular concentrations around 100 nM.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

The analysis

The retrieved papers include direct empirical measurements of resting cytosolic calcium concentration in various cell types (e.g., 95 nM in rat aortic endothelium, an average of 140 nM in embryonic cells, and 118 nM in heart cells). These values consistently support the standard physiological benchmark of approximately 100 nM for resting cytosolic calcium.

Evidence for · 3
Cytosolic calcium concentration in resting and stimulated endothelium of excised intact rat aorta.
1995
Measures resting cytosolic calcium concentration in aortic endothelium at 95 +/- 8 nM, closely aligning with approximately 100 nM.
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Usachev, Y. M., Marchenko, S. M., & Sage, S. O. (1995). Cytosolic calcium concentration in resting and stimulated endothelium of excised intact rat aorta.. doi.org. https://doi.org/10.1113/jphysiol.1995.sp021052

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More for · 2
Cytosolic free calcium-ion concentration in cleaving embryonic cells of Oryzias latipes measured with calcium-selective microelectrodes.
1985
Notes that in most areas of the cytosol, calcium ion concentration remains between 0.01 and 0.40 microM with a mean of 0.14 microM.
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Schantz, A. R. (1985). Cytosolic free calcium-ion concentration in cleaving embryonic cells of Oryzias latipes measured with calcium-selective microelectrodes.. doi.org. https://doi.org/10.1083/jcb.100.3.947

Extent of Increase in Intracellular Calcium Concentration in Electrically Stimulated Chick Embryo Heart Cells Does Not Depend on Resting Intracellular Calcium Concentration
2008
Reports resting intracellular calcium concentrations around 118 nM in one observed cell population of chick embryo heart cells.
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Ahlemeyer, B., Weintraut, H., & Schoner, W. (2008). Extent of Increase in Intracellular Calcium Concentration in Electrically Stimulated Chick Embryo Heart Cells Does Not Depend on Resting Intracellular Calcium Concentration. doi.org. https://doi.org/10.1159/000175948

What does the evidence say?

The retrieved papers include direct empirical measurements of resting cytosolic calcium concentration in various cell types (e.g., 95 nM in rat aortic endothelium, an average of 140 nM in embryonic cells, and 118 nM in heart cells). These values consistently support the standard physiological benchmark of approximately 100 nM for resting cytosolic calcium.

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