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the claim

The insulin-signaling pathway in animals regulates growth, reproduction, metabolic homeostasis, stress resistance and life span.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that the insulin-signaling pathway in animals regulates growth, reproduction, metabolic homeostasis, stress resistance and life span?

Yes. Multiple studies across model organisms confirm that the insulin-signaling pathway evolutionarily regulates growth, metabolism, stress response, reproduction, and lifespan.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked

Evidence for · 4
The TOR pathway interacts with the insulin signaling pathway to regulate <i>C. elegans</i> larval development, metabolism and life span
2004
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Jia, K., Chen, D., & Riddle, D. L. (2004). The TOR pathway interacts with the insulin signaling pathway to regulate
                    <i>C. elegans</i>
                    larval development, metabolism and life span. doi.org. https://doi.org/10.1242/dev.01255

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More for · 3
dFOXO-independent effects of reduced insulin-like signaling in Drosophila
2011
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Slack, C., Giannakou, M., Foley, A., Goss, M., & Partridge, L. (2011). dFOXO-independent effects of reduced insulin-like signaling in Drosophila. doi.org. https://doi.org/10.1111/j.1474-9726.2011.00707.x

Neural pathways in nutrient sensing and insulin signaling
2022
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Ratnaparkhi, A. & Sudhakaran, J. (2022). Neural pathways in nutrient sensing and insulin signaling. doi.org. https://doi.org/10.3389/fphys.2022.1002183

Mechanism of hyperproteinemia-induced damage to female reproduction in a genetic silkworm model
2023
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Jiang, G., Wang, G., Luo, C., Wang, Y., Qiu, J., Peng, R., Sima, Y., & Xu, S. (2023). Mechanism of hyperproteinemia-induced damage to female reproduction in a genetic silkworm model. doi.org. https://doi.org/10.1016/j.isci.2023.107860

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