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the claim

The drug phenobarbital can affect liver function.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
7 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that the drug phenobarbital can affect liver function?

Yes. A pharmacology review states directly that phenobarbital triggers pleiotropic effects on liver function, and several animal and pharmacokinetic studies show phenobarbital altering hepatic enzymes and liver-mediated drug clearance.

Verdict: SUPPORTED · 7 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 7
Phenobarbital increases monkey in vivo nicotine disposition and induces liver and brain CYP2B6 protein
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Phenobarbital increases monkey in vivo nicotine disposition and induces liver and brain CYP2B6 protein. (n.d.). cir.nii.ac.jp. https://doi.org/10.1038/sj.bjp.0706787

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More for · 6
Effect of drugs on heme synthesis in the liver
1971
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Effect of drugs on heme synthesis in the liver. (1971). doi.org. https://doi.org/10.1016/0026-0495(71)90092-8

Anticonvulsant Therapy in Aged Patients
1997
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Anticonvulsant Therapy in Aged Patients. (1997). doi.org. https://doi.org/10.2165/00002512-199710040-00004

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
2000
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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. (2000). doi.org. https://doi.org/10.1038/35038112

Attenuation of phenobarbital‐induced cytochrome P450 expression in carbon tetrachloride‐induced hepatitis in mice models
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Attenuation of phenobarbital‐induced cytochrome P450 expression in carbon tetrachloride‐induced hepatitis in mice models. (n.d.). cir.nii.ac.jp. https://doi.org/10.1002/bdd.2356

Tietz Textbook of Laboratory Medicine - E-Book
2022
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Rifai, N. (2022). Tietz Textbook of Laboratory Medicine - E-Book. play.google.com. https://play.google.com/store/books/details?id=r6RcEAAAQBAJ&source=gbs_api

Phenobarbital Confers its Diverse Effects by Activating the Orphan Nuclear Receptor Car
2006
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Susumu, K. & Masahiko, N. (2006). Phenobarbital Confers its Diverse Effects by Activating the Orphan Nuclear Receptor Car. zenodo.org. https://doi.org/10.1080/03602530600569851

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