The 2014-2015 influenza vaccine had low efficacy against circulating strains
the verdict
SUPPORTED
the evidence backs this
confidence 90/100
Multiple studies and surveillance reports confirm that the 2014-2015 influenza vaccine exhibited low efficacy and reduced protection against circulating H3N2 strains due to significant antigenic drift and mismatch.
Evidence for · 5
Identification of hemagglutinin residues responsible for H3N2 antigenic drift during the 2014–2015 influenza season
2015 · cited by 206
Demonstrates that mutations in the hemagglutinin antigenic site B caused an antigenic mismatch, explaining the low efficacy of the 2014-2015 influenza vaccine.
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More for · 4
H3N2 Mismatch of 2014–15 Northern Hemisphere Influenza Vaccines and Head-to-head Comparison between Human and Ferret Antisera derived Antigenic Maps
2015 · cited by 145
Shows that individuals vaccinated with the 2014-2015 northern hemisphere vaccine experienced a significant reduction in antibody titers against circulating H3N2 epidemic strains.
Interim estimates of 2014/15 vaccine effectiveness against influenza A(H3N2) from Canada's Sentinel Physician Surveillance Network, January 2015.
2015 · cited by 106
Reports that the 2014-2015 vaccine showed little to no protection against circulating A(H3N2) viruses due to substantial antigenic mismatch.
Influenza Vaccine Effectiveness Against Antigenically Drifted Influenza Higher Than Expected in Hospitalized Adults: 2014–2015
2015 · cited by 15
Notes that the 2014-2015 season experienced widespread circulation of antigenically drifted H3N2 viruses with anticipated low vaccine effectiveness.
Influenza - the need to stay ahead of the virus.
2015 · cited by 5
Synthesizes multiple reports showing substantially reduced vaccine effectiveness during the 2014-2015 season due to antigenic mismatch.