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the claim

Testosterone therapy increases the risk of venous blood clots.

the verdict
CONTESTED PARTIAL
Recorded sources
6 sources for · 2 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that testosterone therapy increases the risk of venous blood clots?

Partly. Evidence on whether testosterone therapy raises venous clot risk is mixed and partial: several observational and trial reports note higher pulmonary embolism rates or a possible early risk window, while a review and a cohort of women on estradiol plus testosterone report no clear increase. No single source settles the general claim at full strength.

Verdict: CONTESTED PARTIAL · 6 sources for, 2 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 6
Does Testosterone Replacement Therapy Increase Risk of Thrombosis After Total Hip or Knee Arthroplasty?
2026
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A, N., E, C., V, M., CR, G., CC, M., & F, B. (2026). Does Testosterone Replacement Therapy Increase Risk of Thrombosis After Total Hip or Knee Arthroplasty?. doi.org. https://doi.org/10.1016/j.arth.2025.11.040

Evidence against · 2
Cardiovascular disease and testosterone therapy in male hypogonadism
2024
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Cardiovascular disease and testosterone therapy in male hypogonadism. (2024). doi.org. https://doi.org/10.1111/nyas.15211

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More for · 5
Testosterone Therapy as an Isolated Risk Factor for Venous Thrombosis: A Case Report -
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Testosterone Therapy as an Isolated Risk Factor for Venous Thrombosis: A Case Report - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.7759/cureus.63611

Effect of testosterone on blood-clotting markers in transsexual men
2025
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Reis, E. T. S. d., Dias, C. M. F., Vieira, C. S., Nadai, M., Okano, S. P., Franceschini, S. A., & Lara, L. A. d. S. (2025). Effect of testosterone on blood-clotting markers in transsexual men. doi.org. https://doi.org/10.1016/j.htct.2025.103862

Testosterone replacement therapy and non‑major adverse cardiovascular event safety signals: Atrial fibrillation, acute kidney injury, and pulmonary embolism.
2026
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L, S., M, M., H, K., M, A., M, P., & A, D. (2026). Testosterone replacement therapy and non‑major adverse cardiovascular event safety signals: Atrial fibrillation, acute kidney injury, and pulmonary embolism.. doi.org. https://doi.org/10.33963/v.phj.111620

Androgen replacement therapy
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Androgen replacement therapy. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Androgen_replacement_therapy

Masculinizing hormone therapy
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Masculinizing hormone therapy. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Masculinizing_hormone_therapy

More against · 1
Incidence of venous thromboembolism in women receiving transdermal oestradiol/testosterone with micronised progesterone in accordance with NICE guidelines.
2026
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A, N., D, R., J, B., M, K., & L, N. (2026). Incidence of venous thromboembolism in women receiving transdermal oestradiol/testosterone with micronised progesterone in accordance with NICE guidelines.. doi.org. https://doi.org/10.21037/tau-2025-662

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