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the claim

Testosterone replacement therapy suppresses sperm production and causes sterility in men.

the verdict
CONTESTED PARTIAL
Recorded sources
5 sources for · 1 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that testosterone replacement therapy suppresses sperm production and causes sterility in men?

Partly. Several reviews and studies confirm that testosterone replacement therapy suppresses spermatogenesis and can cause azoospermia while on treatment, but the same sources report that sperm production typically resumes after stopping, so the claim's sterility component is only partially supported and partly contradicted.

Verdict: CONTESTED PARTIAL · 5 sources for, 1 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 5
Testosterone replacement therapy in men who conceived with intracytoplasmic sperm injection: nationwide register study
2020
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Elenkov, A., Al-Jebari, Y., Giwercman, Y. L., & Giwercman, A. (2020). Testosterone replacement therapy in men who conceived with intracytoplasmic sperm injection: nationwide register study. doi.org. https://doi.org/10.1530/eje-19-0734

Evidence against · 1
Direct conversion from long‐acting testosterone replacement therapy to Natesto allows for spermatogenesis resumption: Proof of concept
2022
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Direct conversion from long‐acting testosterone replacement therapy to Natesto allows for spermatogenesis resumption: Proof of concept. (2022). doi.org. https://doi.org/10.1111/and.14453

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More for · 4
Clomiphene citrate versus testosterone replacement therapy in male hypogonadism: a systematic review of literature and meta-analysis.
2026
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BT, C., BC, B., L, G., BN, S., CMO, M., MMG, P., B, U., RS, M., RAS, d. S., R, F., & JA, S. d. C. (2026). Clomiphene citrate versus testosterone replacement therapy in male hypogonadism: a systematic review of literature and meta-analysis.. doi.org. https://doi.org/10.1007/s00228-026-04134-3

Testosterone replacement therapy and spermatogenesis in reproductive age men
2025
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Testosterone replacement therapy and spermatogenesis in reproductive age men. (2025). doi.org. https://doi.org/10.1038/s41585-025-01032-8

Exogenous testosterone: a preventable cause of male infertility
2013
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Crosnoe, L. E., Grober, E., Ohl, D., & Kim, E. (2013). Exogenous testosterone: a preventable cause of male infertility. doi.org. https://doi.org/10.3978/j.issn.2223-4683.2013.06.01

Exogenous testosterone: a preventable cause of male infertility.
2013
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Exogenous testosterone: a preventable cause of male infertility.. (2013). pubmed.ncbi.nlm.nih.gov. https://pubmed.ncbi.nlm.nih.gov/26813847

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