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the claim

Taking antidepressants causes weight gain in patients.

the verdict
INSUFFICIENT LEANING
Recorded sources
6 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that taking antidepressants causes weight gain in patients?

Unclear. Several sources associate antidepressant use with weight gain: a comparative analysis reports higher weight gain with escitalopram, paroxetine and duloxetine than sertraline, and a small observational study lists weight gain among the most frequent adverse reactions. Other items only mention weight gain as background or as increased appetite, so the evidence covers part of the claim rather than establishing a general causal effect.

Verdict: PARTIAL LEAN · 6 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 6
Pharmacology of antidepressants
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Pharmacology of antidepressants. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Pharmacology_of_antidepressants

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More for · 5
Which Antidepressants Cause the Most Weight Gain?
2025
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Zarkowski, P. (2025). Which Antidepressants Cause the Most Weight Gain?. doi.org. https://doi.org/10.64239/pi-qt7202

A comprehensive approach to predicting weight gain and therapy response in psychopharmacologically treated major depressed patients: A cohort study protocol
2022
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Simon, M. S., Barton, B. B., Glocker, C., & Musil, R. (2022). A comprehensive approach to predicting weight gain and therapy response in psychopharmacologically treated major depressed patients: A cohort study protocol. doi.org. https://doi.org/10.1371/journal.pone.0271793

Developing a machine learning algorithm to predict psychotropic drugs-induced weight gain and the effectiveness of anti-obesity drugs in patients with severe mental illness: Protocol for a prospective cohort study
2025
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Lee, H. J., Kim, N. Y., Kim, D. S., Kim, Y., Kim, J., & Han, D. H. (2025). Developing a machine learning algorithm to predict psychotropic drugs-induced weight gain and the effectiveness of anti-obesity drugs in patients with severe mental illness: Protocol for a prospective cohort study. doi.org. https://doi.org/10.1371/journal.pone.0324000

Gastrointestinal side effects associated with antidepressant treatments in patients with major depressive disorder: A systematic review and meta-analysis.
2021
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Oliva, V., Lippi, M., Paci, R., Fabro, L. D., Delvecchio, G., Brambilla, P., Ronchi, D. D., Fanelli, G., & Serretti, A. (2021). Gastrointestinal side effects associated with antidepressant treatments in patients with major depressive disorder: A systematic review and meta-analysis.. doi.org. https://doi.org/10.1016/j.pnpbp.2021.110266

Comparative Efficacy and Safety of SSRIs and TCAs in the Management of Major Depressive Disorder: A Prospective Observational Study
2025
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Jena, P. P., Bhabagrahi, R., & Narayan, N. B. (2025). Comparative Efficacy and Safety of SSRIs and TCAs in the Management of Major Depressive Disorder: A Prospective Observational Study. doi.org. https://doi.org/10.4103/jpbs.jpbs_1249_25

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