Sunlight triggers lupus flare-ups through ultraviolet radiation effects on skin cells
the verdict
SUPPORTED
the evidence backs this
confidence 88/100
Current scientific literature supports the consensus that ultraviolet radiation acts as an environmental trigger that can induce skin cell damage and provoke flare-ups in lupus erythematosus.
Evidence for · 4
Ultraviolet radiation and systemic lupus erythematosus
2014 · cited by 97
Paper [0] notes that ultraviolet radiation exposure is a known environmental factor that may exacerbate pre-existing lupus.
See more details
More for · 3
[Ultraviolet radiation in the pathogenesis of lupus erythematosus].
2024 · cited by 4
Paper [2] states that cutaneous and systemic lupus erythematosus flare-ups can be provoked by ultraviolet radiation.
From Genes to Pathways: The Molecular Landscape of Systemic Lupus Erythematosus.
2026 · cited by 0
Paper [4] indicates that environmental triggers like ultraviolet radiation initiate bursts of nucleic acid release and immune activation driving lupus pathogenesis.
Environmental Exposures of Concern for Rheumatologists: Ultraviolet Radiation.
2026 · cited by 0
Paper [5] highlights that ultraviolet radiation induces both local and systemic immune dysregulation through DNA damage and autoantigen exposure in lupus patients.