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the claim

Statin therapy increases blood levels of lipoprotein(a) in patients with high cholesterol.

the verdict
CONTESTED
the evidence cuts both ways
Recorded sources
2 sources for · 1 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Statin therapy increases blood levels of lipoprotein(a) in patients with high cholesterol?

Partly. A subject-level meta-analysis of six randomized trials reports that statins significantly increase plasma lipoprotein(a) levels, while a separate patient-level meta-analysis of seven statin outcome trials found no significant change in lipoprotein(a) with statin initiation. The two peer-reviewed meta-analyses therefore disagree on whether statin therapy raises lipoprotein(a).

Verdict: CONTESTED · 2 sources for, 1 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 2
Statin therapy increases lipoprotein(a) levels.
2020
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S, T., PLSM, G., C, N., C, Y., & JL, W. (2020). Statin therapy increases lipoprotein(a) levels.. doi.org. https://doi.org/10.1093/eurheartj/ehz310

Evidence against · 1
Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials.
2018
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Willeit, P., Ridker, P. M., Nestel, P. J., Simes, J., Tonkin, A. M., Pedersen, T. R., Schwartz, G. G., Olsson, A. G., Colhoun, H. M., Kronenberg, F., Drechsler, C., Wanner, C., Mora, S., Lesogor, A., & Tsimikas, S. (2018). Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials.. doi.org. https://doi.org/10.1016/S0140-6736(18)31652-0

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More for · 1
Statins and Lp(a) – the plot thickens -
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Statins and Lp(a) – the plot thickens - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1016/j.atherosclerosis.2019.07.021

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