Spike-timing-dependent plasticity and homeostatic plasticity operate through different biological mechanisms
the verdict
SUPPORTED
the evidence backs this
confidence 84/100
Spike-timing-dependent plasticity and homeostatic plasticity are distinct forms of synaptic modification that rely on divergent cellular and molecular signaling pathways.
Evidence for · 2
Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex
2020 · cited by 29
Paper 1 details specific molecular mechanisms underlying spike-timing-dependent plasticity (endocannabinoids, astrocytic calcium signaling, and presynaptic NMDARs with calcineurin).
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More for · 1
Distinct molecular pathways govern presynaptic homeostatic plasticity
2020 · cited by 2
Paper 7 identifies distinct molecular signaling pathways (such as Protein Kinase D and specific GluR subtypes) governing homeostatic plasticity.