Specific therapies reduce immune over-reaction in sepsis
the verdict
SUPPORTED
the evidence backs this
confidence 79/100
Multiple studies demonstrate that targeted therapies, including cytokine inhibitors, nanotherapeutics, and stem cell treatments, effectively mitigate immune over-reaction and organ damage during sepsis.
Evidence for · 6
The "cytokine storm" in infection and sepsis: win the battle but lose the war.
2026 · cited by 3
This review highlights that therapeutic strategies such as cytokine antagonists, JAK inhibitors, and glucocorticoids aim to interrupt self-amplifying inflammation and reduce multiorgan dysfunction in sepsis.
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More for · 5
mRNA nanotherapeutics for sepsis: immune modulation strategies and translational challenges.
2026 · cited by 1
Preclinical studies demonstrate that mRNA-based nanotherapeutics can suppress cytokine storms, restore immune function, and attenuate organ injury in experimental models of sepsis.
Interleukin-10-engineered mesenchymal stem/stromal cells exhibit robust immunomodulatory effects in vitro and in vivo.
2026 · cited by 0
Genetically modified mesenchymal stem cells expressing IL-10 significantly reduced systemic pro-inflammatory cytokines and mitigated tissue damage in sepsis models.
Multi-targeted biomimetic CeO₂-based nanoplatform for sepsis therapy via mitochondrial homeostasis.
2026 · cited by 0
A bionic nanotherapeutic system integrating ROS scavenging and macrophage-membrane coating effectively reduced systemic inflammatory cytokines and alleviated multi-organ injury in a sepsis model.
Reverse-Engineered Lipid Nanoparticles Harness Protein Corona Formation for Cytokine Sequestration and Combination Immunomodulatory Therapy.
2026 · cited by 0
A dual-function nanoplatform successfully sequestered pathological cytokines and delivered dexamethasone, attenuating systemic inflammation and improving survival in sepsis models.
Adjuvant intravenous immunoglobulin in elderly sepsis: a randomized controlled study of mortality, organ function, and inflammation.
2026 · cited by 0
Adjunctive intravenous immunoglobulin therapy in elderly sepsis patients was associated with reduced systemic inflammation and accelerated recovery of organ function.