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the claim

Some archaeal cell membranes are structured as lipid monolayers rather than lipid bilayers.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that some archaeal cell membranes are structured as lipid monolayers rather than lipid bilayers?

Yes. Multiple studies and molecular dynamics simulations confirm that certain archaeal membranes are composed of bipolar tetraether lipids organized into lipid monolayers rather than traditional bilayers.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked

The analysis

The retrieved papers consistently confirm that archaea possess bipolar tetraether lipids (bolalipids) capable of spanning the membrane and forming stable lipid monolayers, supported by both experimental extraction and molecular dynamics simulations.

Evidence for · 5
Transfection Studies with Colloidal Systems Containing Highly Purified Bipolar Tetraether Lipids from<i>Sulfolobus acidocaldarius</i>
2017
Utilizes highly purified tetraether lipids from Sulfolobus acidocaldarius to form stable liposomes and vectors.
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Engelhardt, K. H., Pinnapireddy, S. R., Baghdan, E., Jedelská, J., & Bakowsky, U. (2017). Transfection Studies with Colloidal Systems Containing Highly Purified Bipolar Tetraether Lipids from<i>Sulfolobus acidocaldarius</i>. doi.org. https://doi.org/10.1155/2017/8047149

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More for · 4
A molecular dynamics study of an archaeal tetraether lipid membrane: Comparison with a dipalmitoylphosphatidylcholine lipid bilayer
2005
Performs molecular dynamics simulations showing that an archaeal membrane made of bipolar tetraether lipids forms a pure lipid monolayer.
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Nicolas, J. P. (2005). A molecular dynamics study of an archaeal tetraether lipid membrane: Comparison with a dipalmitoylphosphatidylcholine lipid bilayer. doi.org. https://doi.org/10.1007/s11745-005-1465-2

Bilayer-Forming Lipids Enhance Archaeal Monolayer Membrane Stability.
2025
Discusses tetraether lipids conferring structural integrity to archaeal membranes by forming monolayers.
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M, S., P, S., M, T., SV, A., Y, L., J, P., B, D., S, F., & PM, O. (2025). Bilayer-Forming Lipids Enhance Archaeal Monolayer Membrane Stability.. doi.org. https://doi.org/10.3390/ijms26073045

Bilayer-forming lipids enhance archaeal monolayer membrane stability
2025
Refers to monolayer-forming tetraethers and their structural organization in archaeal-like lipid assemblies.
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Saracco, M., Schaeffer, P., Tourte, M., Albers, S., Louis, Y., Peters, J., Demé, B., Fontanay, S., & Oger, P. (2025). Bilayer-forming lipids enhance archaeal monolayer membrane stability. doi.org. https://doi.org/10.1101/2025.02.20.639260

Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid organization.
2026
Notes that archaeal membranes are composed of mixtures including bolalipids that form monolayer structures.
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F, F., M, A., & A, Š. (2026). Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid organization.. doi.org. https://doi.org/10.1063/5.0325170

What does the evidence say?

The retrieved papers consistently confirm that archaea possess bipolar tetraether lipids (bolalipids) capable of spanning the membrane and forming stable lipid monolayers, supported by both experimental extraction and molecular dynamics simulations.

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