trustmebro.to/r/…
✓ checked
trust me, bro:
here is the receipt.
the claim

Sertraline use is associated with an increased risk of bleeding.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 1 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Sertraline use is associated with an increased risk of bleeding?

Yes. Current pharmacovigilance data and clinical reviews indicate that sertraline use, particularly when combined with antiplatelet or anticoagulant medications or in elderly populations, is associated with an increased risk of bleeding events.

Verdict: SUPPORTED · 5 sources for, 1 against · Last checked

The analysis

Multiple large-scale pharmacovigilance studies and reviews (such as [0], [3], [4], [5], and [7]) consistently report bleeding signals—including gastrointestinal and intracranial hemorrhage—associated with sertraline and other selective serotonin reuptake inhibitors, especially in high-risk groups or concurrent with antithrombotics. Conversely, one meta-analysis on stroke outcomes ([8]) found no significant increase in bleeding events specifically in that clinical context. Weighing the robust pharmacovigilance data and established class-wide warnings against the neutral stroke finding, the evidence clearly favors the association of sertraline use with an increased risk of bleeding.

Evidence for · 5
Selective Serotonin Reuptake Inhibitor-Associated Intracranial Hemorrhage: Drug-Specific Risk Patterns and Patient-Level Modifiers.
2025
Sertraline showed strong disproportionate reporting signals for cerebral hemorrhage and intracranial hemorrhage, particularly in elderly patients and when combined with anticoagulants.
Get citation
J, Y. & K, R. (2025). Selective Serotonin Reuptake Inhibitor-Associated Intracranial Hemorrhage: Drug-Specific Risk Patterns and Patient-Level Modifiers.. doi.org. https://doi.org/10.3390/neurolint17070111

Evidence against · 1
The influence of selective serotonin reuptake inhibitors on stroke outcome: a systematic review and meta-analysis.
2026
A systematic review and meta-analysis of stroke outcomes observed no statistically significant differences in bleeding events associated with SSRI use.
Get citation
Y, S. & S, M. (2026). The influence of selective serotonin reuptake inhibitors on stroke outcome: a systematic review and meta-analysis.. doi.org. https://doi.org/10.3389/fneur.2026.1894976

See more details
More for · 4
Pharmacovigilance Analysis of Bleeding Events Associated With Selective Serotonin Reuptake Inhibitors (SSRIs) Using the US Food and Drug Administration Adverse Event Reporting System (FAERS).
2026
A large-scale pharmacovigilance analysis of FAERS data demonstrated that sertraline accounted for a substantial absolute number of bleeding reports among SSRIs.
Get citation
ACY, C. (2026). Pharmacovigilance Analysis of Bleeding Events Associated With Selective Serotonin Reuptake Inhibitors (SSRIs) Using the US Food and Drug Administration Adverse Event Reporting System (FAERS).. doi.org. https://doi.org/10.7759/cureus.110163

Association between concomitant use of direct oral anticoagulants with antidepressants and an increased risk of hemorrhage: analysis of the food and drug administration adverse event reporting system database.
2026
Co-administration of SSRIs with direct oral anticoagulants was significantly associated with an increased risk of hemorrhage.
Get citation
Y, R., Y, Z., Y, C., & H, L. (2026). Association between concomitant use of direct oral anticoagulants with antidepressants and an increased risk of hemorrhage: analysis of the food and drug administration adverse event reporting system database.. doi.org. https://doi.org/10.3389/fmed.2026.1765791

Prevention of Gastrointestinal Bleeding in Patients Receiving Direct Oral Anticoagulants: A Narrative Review and Practical Framework for Prescribers.
2026
SSRIs are recognized as established risk factors contributing to gastrointestinal bleeding when used alongside anticoagulants.
Get citation
N, D., L, A., LC, B., RA, S., C, P., MO, B., BS, T., BȘ, P., & C, S. (2026). Prevention of Gastrointestinal Bleeding in Patients Receiving Direct Oral Anticoagulants: A Narrative Review and Practical Framework for Prescribers.. doi.org. https://doi.org/10.3390/clinpract16070120

Safety Concerns, Mechanistic Pathways, and Knowledge Gaps in the Clinical Use of Selective Serotonin Reuptake Inhibitors.
2026
Gastrointestinal bleeding and other hemorrhagic complications are highlighted among the well-documented safety concerns associated with long-term SSRI use.
Get citation
ACY, C. (2026). Safety Concerns, Mechanistic Pathways, and Knowledge Gaps in the Clinical Use of Selective Serotonin Reuptake Inhibitors.. doi.org. https://doi.org/10.7759/cureus.100719

What does the evidence say?

Multiple large-scale pharmacovigilance studies and reviews (such as [0], [3], [4], [5], and [7]) consistently report bleeding signals—including gastrointestinal and intracranial hemorrhage—associated with sertraline and other selective serotonin reuptake inhibitors, especially in high-risk groups or concurrent with antithrombotics. Conversely, one meta-analysis on stroke outcomes ([8]) found no significant increase in bleeding events specifically in that clinical context. Weighing the robust pharmacovigilance data and established class-wide warnings against the neutral stroke finding, the evidence clearly favors the association of sertraline use with an increased risk of bleeding.

Receipt History
Anyone with this link can read the claim and its public receipt, including any personal information in that text. Open permanent receipt.
Check your own claim
Challenge the receipt
Requests are recorded for review. This does not start an automatic check or guarantee a response time.

See the evidence timeline

Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.

This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work