SerpinB3 plays a specific functional role in human physiological and pathological processes
the verdict
SUPPORTED
the evidence backs this
confidence 90/100
Multiple studies demonstrate that SerpinB3 plays critical functional roles in both physiological and pathological processes, notably regulating oxidative stress responses, tissue protection, and cancer progression.
Evidence for · 6
Update of the human and mouse SERPINgene superfamily
2013 · cited by 274
Highlights the serpin superfamily and notes their functional diversity across physiological and pathological processes including tumorigenesis and inflammation.
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More for · 5
SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I
2013 · cited by 63
Demonstrates that SERPINB3 plays a specific functional role in protecting cells from oxidative stress and chemotherapy-induced apoptosis by inhibiting mitochondrial respiratory complex I.
The protease‐inhibitor SerpinB3 as a critical modulator of the stem‐like subset in human cholangiocarcinoma
2021 · cited by 63
Shows that SerpinB3 acts as a critical modulator of the stem-like phenotype and malignant behavior in cholangiocarcinoma.
Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells
2014 · cited by 61
Finds that hypoxia up-regulates SERPINB3 via HIF-2alpha, indicating a specific role for SERPINB3 in cancer cell responses and oncogenesis.
SERPINB3 is associated with TGF-β1 and cytoplasmic β-catenin expression in hepatocellular carcinomas with poor prognosis
2014 · cited by 59
Establishes that high SERPINB3 expression correlates with aggressive molecular signatures and poor prognosis in hepatocellular carcinomas.
SerpinB3: A Multifaceted Player in Health and Disease-Review and Future Perspectives.
2024 · cited by 10
Reviews the multifaceted roles of SerpinB3, confirming its involvement in carcinogenesis, fibrosis, metabolic regulation, and tissue protection.