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the claim

Redheads have a different pain threshold from other people because of MC1R gene variants.

the verdict
INSUFFICIENT LEANING
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Redheads have a different pain threshold from other people because of MC1R gene variants?

Unclear. Several reviews and small studies report that MC1R variants and red hair are associated with altered pain sensitivity and analgesic response, but the same sources stress small samples, few genotyped studies, and difficulty drawing general conclusions.

Verdict: PARTIAL LEAN · 5 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 5
Redheads and pain receptors
2015
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Redheads and pain receptors. (2015). biology.stackexchange.com. https://biology.stackexchange.com/questions/28590/redheads-and-pain-receptors

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More for · 4
Red-Haired People’s Altered Responsiveness to Pain, Analgesics, and Hypnotics: Myth or Fact?—A Narrative Review -
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Red-Haired People’s Altered Responsiveness to Pain, Analgesics, and Hypnotics: Myth or Fact?—A Narrative Review - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.3390/jpm14060583

Involvement of the Melanocortin-1 Receptor in Acute Pain and Pain of Inflammatory but Not Neuropathic Origin
2010
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Delaney, A., Keighren, M., Fleetwood-Walker, S. M., & Jackson, I. J. (2010). Involvement of the Melanocortin-1 Receptor in Acute Pain and Pain of Inflammatory but Not Neuropathic Origin. doi.org. https://doi.org/10.1371/journal.pone.0012498

Pain sensitivity and experimentally induced sensitisation in red haired females
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Pain sensitivity and experimentally induced sensitisation in red haired females. (n.d.). cir.nii.ac.jp. https://doi.org/10.1016/j.sjpain.2010.08.005

A Comparative Analysis of the Efficacy of Local Anesthetics and Systemic Anesthetics in the Red-Headed Versus Non-Red-Headed Patient Population: A Comprehensive Review.
2024
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CR, M., VE, P., BL, F., AT, S., & M, A. (2024). A Comparative Analysis of the Efficacy of Local Anesthetics and Systemic Anesthetics in the Red-Headed Versus Non-Red-Headed Patient Population: A Comprehensive Review.. doi.org. https://doi.org/10.7759/cureus.61797

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