Proton pump inhibitors shut down proton pumps in all cells across the body
the verdict
REFUTED
the evidence says no
confidence 18/100
Proton pump inhibitors do not affect proton pumps across all cells in the body; rather, they specifically target the hydrogen-potassium ATPase pumps located within gastric parietal cells to suppress stomach acid secretion.
Evidence against · 4
25 Years of Proton Pump Inhibitors: A Comprehensive Review
2016 · cited by 663
Paper 0 notes that PPIs specifically inhibit active parietal cell acid secretion rather than proton pumps across all cells in the body.
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More against · 3
Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors
2013 · cited by 399
Paper 2 discusses how PPIs specifically target and bind covalently to the gastric H+, K+-ATPase in parietal cells.
The Physiology of the Gastric Parietal Cell
2019 · cited by 288
Paper 3 describes parietal cells as the unique cells responsible for gastric acid secretion via the H+-K+-ATPase enzyme.
[Current status and prospects of using potassium-competitive acid blockers in gastroenterology].
2025 · cited by 4
Paper 6 explains that PPIs and P-CABs act specifically on hydrogen potassium adenosine triphosphatase in the parietal cells of the stomach.