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Paget's disease of bone can cause pain in the affected bones.

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SUPPORTED
the evidence backs this
Recorded sources
9 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Paget's disease of bone can cause pain in the affected bones?

Yes. Multiple reference and peer-reviewed sources state that bone pain is a symptom of Paget's disease of bone, with an official NIAMS page calling it the most common symptom and a Wikipedia article noting affected bones may cause pain.

Verdict: SUPPORTED · 9 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 9
Paget's disease of bone
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Paget's disease of bone. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Paget's_disease_of_bone

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More for · 8
Paget's Disease of Bone
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Paget's Disease of Bone. (n.d.). cir.nii.ac.jp. https://doi.org/10.1359/jbmr.1998.13.7.1061

Determinants of quality of life in Paget's disease of bone
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Castro, G. R. W. d., Castro, S. A. F. d., Pereira, I. A., Zimmermann, A. F., Toscano, M. A., & Neves, F. S. (n.d.). Determinants of quality of life in Paget's disease of bone. doi.org. https://doi.org/10.1016/j.rbre.2017.06.002

Paget's Disease of Bone Symptoms & Risk Factors| NIAMSLock
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Paget's Disease of Bone Symptoms & Risk Factors| NIAMSLock. (n.d.). niams.nih.gov. https://www.niams.nih.gov/health-topics/pagets-disease-bone

Mechanisms of disease: genetics of Paget's disease of bone and related disorders.
2006
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A, D. & SH, R. (2006). Mechanisms of disease: genetics of Paget's disease of bone and related disorders.. doi.org. https://doi.org/10.1038/ncprheum0172

Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline.
2019
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Ralston, S. H., Corral-Gudino, L., Cooper, C., Francis, R. M., Fraser, W. D., Gennari, L., Guañabens, N., Javaid, M. K., Layfield, R., O'Neill, T. W., Russell, R. G. G., Stone, M. D., Simpson, K., Wilkinson, D., Wills, R., Zillikens, M. C., & Tuck, S. P. (2019). Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline.. doi.org. https://doi.org/10.1002/jbmr.3657

Quantitative Sensory Testing Reveals Evidence of Altered Pain Processing in Paget's Disease of Bone.
2025
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K, B., DM, D., L, C., JCY, T., T, A., E, D., H, D., N, G., E, H., R, K., E, M., TW, O., F, R., M, S., S, T., J, T., & SH, R. (2025). Quantitative Sensory Testing Reveals Evidence of Altered Pain Processing in Paget's Disease of Bone.. doi.org. https://doi.org/10.1007/s00223-025-01456-9

Anti-osteoclastic agent, denosumab, for a giant cell tumor of the bone with concurrent Paget's disease: A case report
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Anti-osteoclastic agent, denosumab, for a giant cell tumor of the bone with concurrent Paget's disease: A case report. (n.d.). cir.nii.ac.jp. https://doi.org/10.3892/ol.2017.5693

Paget's Disease of the Spine as a Catalyst for Osteosarcoma: A Narrative Review.
2026
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GF, D. R. M., K, Y., A, A., L, L., M, E., JP, J., LA, B., & A, M. (2026). Paget's Disease of the Spine as a Catalyst for Osteosarcoma: A Narrative Review.. doi.org. https://doi.org/10.7759/cureus.109625

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