NSAIDs such as naproxen facilitate the passage of kidney stones
the verdict
REFUTED
the evidence says no
confidence 10/100
Contrary to the claim that NSAIDs facilitate the passage of kidney stones, recent Mendelian randomization studies indicate that NSAIDs are actually associated with an increased risk of developing kidney stones.
Evidence against · 2
Associations of genetic proxies for non-steroidal anti-inflammatory drugs with increased kidney stone risk: a Mendelian randomization study.
2025 · cited by 0
Mendelian randomization analysis indicates that genetically proxied lower NEU1 expression related to NSAIDs is associated with an increased risk of kidney stones, rather than facilitating their passage.
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More against · 1
Nonsteroidal anti-inflammatory drugs, blood metabolites, and kidney stones: a comprehensive Mendelian randomization study.
2025 · cited by 0
A comprehensive two-sample Mendelian randomization study found that NSAIDs usage is causally associated with an increased risk of kidney stone formation rather than helping pass existing stones.