NSAIDs, including ibuprofen, can cause serious gastrointestinal adverse events such as inflammation, bleeding, ulceration, and perforation of the stomach or intestines.
Is it true that NSAIDs, including ibuprofen, can cause serious gastrointestinal adverse events such as inflammation, bleeding, ulceration, and perforation of the stomach or intestines?
Yes. Nonsteroidal anti-inflammatory drugs, including ibuprofen, are well-documented to cause serious upper and lower gastrointestinal complications, such as mucosal inflammation, bleeding, and peptic ulceration.
Verdict: SUPPORTED · 7 sources for, 0 against · Last checked
The retrieved papers consistently support the well-established medical consensus that NSAID use causes serious gastrointestinal adverse events, including bleeding, inflammation, and ulceration. Multiple studies explicitly discuss NSAID-induced ulcers, mucosal damage, and gastrointestinal bleeding risks, supporting the claim without any refuting evidence.
Get citation
McDonald, D. D. (2019). Predictors of gastrointestinal bleeding in older persons taking nonsteroidal anti-inflammatory drugs: Results from the FDA adverse events reporting system. doi.org. https://doi.org/10.1097/jxx.0000000000000130
See more details
Get citation
H, F., S, F., T, Y., T, M., T, T., K, O., Y, T., & T, M. (2024). Investigation of the effects of a new transdermal formulation of systemic diclofenac on the upper gastrointestinal mucosa in patients with low back pain: A comparative study with oral diclofenac.. doi.org. https://doi.org/10.1111/jgh.16810
Get citation
SG, K., TO, K., SW, J., BH, M., JH, O., HS, K., GH, L., JH, S., IK, S., YS, C., SC, C., YJ, L., BW, K., CM, S., CW, H., JW, K., KO, K., YK, C., OY, L., JS, M., HW, L., HY, J., WG, S., JG, K., JY, L., SJ, H., SW, K., JH, C., H, L., TH, K., MI, P., GH, B., RR, C., SK, L., & JJ, K. (2026). A Phase III, Randomized, Double-Blind, Active-Controlled, Multicenter Study Evaluating the Safety and Efficacy of Tegoprazan for the Prevention of Peptic Ulcer in Patients on Continuous Long-Term Treatment with Nonsteroidal Anti-Inflammatory Drugs.. doi.org. https://doi.org/10.5009/gnl260057
Get citation
F, A., MM, A., E, A. J., Z, A., & A, A. J. (2025). Physicians' attitudes toward gastroprotective strategies for nonsteroidal anti-inflammatory drug prescription.. doi.org. https://doi.org/10.1080/08998280.2024.2418779
Get citation
H, L., JW, C., KO, K., KA, K., & JH, K. (2026). Pharmacological Management of Peptic Ulcer Bleeding.. doi.org. https://doi.org/10.7704/kjhugr.2025.0075
Get citation
N, D., L, A., LC, B., RA, S., C, P., MO, B., BS, T., BȘ, P., & C, S. (2026). Prevention of Gastrointestinal Bleeding in Patients Receiving Direct Oral Anticoagulants: A Narrative Review and Practical Framework for Prescribers.. doi.org. https://doi.org/10.3390/clinpract16070120
Get citation
M, S., T, K., M, I., J, I., T, O., S, O., T, K., T, C., K, T., S, N., T, M., T, W., D, A., E, I., T, W., H, O., R, K., S, K., N, K., S, S., A, S., H, S., H, C., D, C., O, D., A, N., A, H., Y, H., K, M., K, M., D, M., J, M., H, M., S, Y., J, W., K, S., Y, M., A, T., Y, T., S, E., S, W., H, I., T, I., & S, M. (2026). Evidence-based clinical practice guidelines for peptic ulcer disease 2026.. doi.org. https://doi.org/10.1007/s00535-026-02504-3
What does the evidence say?
The retrieved papers consistently support the well-established medical consensus that NSAID use causes serious gastrointestinal adverse events, including bleeding, inflammation, and ulceration. Multiple studies explicitly discuss NSAID-induced ulcers, mucosal damage, and gastrointestinal bleeding risks, supporting the claim without any refuting evidence.
Challenge the receipt
Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.
Terms · Privacy · How verdicts work