NSAIDs harm the kidneys by blocking prostaglandins that maintain renal blood flow.

the verdict

SUPPORTED

the evidence backs this

Recorded sources

7 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that NSAIDs harm the kidneys by blocking prostaglandins that maintain renal blood flow?

Yes. One review states NSAIDs inhibit vasodilatory renal prostaglandins via cyclooxygenase, causing vasomotor acute kidney injury, and a mouse study links NSAID prostaglandin inhibition to harmful renal blood flow effects; other sources partially confirm prostaglandin inhibition or renal injury but not the full mechanism.

Verdict: SUPPORTED · 7 sources for, 0 against · Last checked 3 Oct 2026

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 7

Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Periodontology: A Narrative Review

2026

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Aayushi, A. (2026). Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Periodontology: A Narrative Review. zenodo.org. https://doi.org/10.5281/zenodo.19511028

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More for · 6

Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature -

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Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1002/prp2.817

Increased severity of renal impairment in nephritic mice lacking the EP 1 receptor

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Increased severity of renal impairment in nephritic mice lacking the EP 1 receptor. (n.d.). cir.nii.ac.jp. https://doi.org/10.1139/y06-029

Primer on Kidney Diseases E-Book

2009

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Greenberg, A. (2009). Primer on Kidney Diseases E-Book. books.google.com. http://books.google.com/books?id=mYnBVFHwB3UC&dq=NSAIDs+harm+the+kidneys+by+blocking+prostaglandins+that+maintain+renal+blood+flow.&hl=&as_pt=BOOKS&source=gbs_api

Kidney Protection

2019

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Lapsia, V., Jaar, B., & Ejaz, A. A. (2019). Kidney Protection. play.google.com. https://play.google.com/store/books/details?id=0hCIDwAAQBAJ&source=gbs_api

Campbell-Walsh Urology

2011

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Wein, A. J., Kavoussi, L. R., Novick, A. C., Partin, A. W., & Peters, C. A. (2011). Campbell-Walsh Urology. books.google.com. http://books.google.com/books?id=W1aeyJD46kIC&dq=NSAIDs+harm+the+kidneys+by+blocking+prostaglandins+that+maintain+renal+blood+flow.&hl=&as_pt=BOOKS&source=gbs_api

WAYS TO PREVENT SIDE EFFECTS OF NONSTEROIDAL DRUGS

2025

Get citation

Islombek, S. (2025). WAYS TO PREVENT SIDE EFFECTS OF NONSTEROIDAL DRUGS. zenodo.org. https://doi.org/10.5281/zenodo.14752771

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