trustmebro.to/r/…
✓ checked
trust me, bro:
here is the receipt.
the claim

Non-arteritic anterior ischemic optic neuropathy, which can cause permanent vision loss, has been reported rarely in association with the use of PDE5 inhibitors like tadalafil.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Non-arteritic anterior ischemic optic neuropathy, which can cause permanent vision loss, has been reported rarely in association with the use of PDE5 inhibitors like tadalafil?

Yes. Non-arteritic anterior ischemic optic neuropathy has been reported as a rare adverse effect associated with the use of phosphodiesterase-5 inhibitors.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

The analysis

The claim states that NAION has been reported rarely in association with PDE5 inhibitors like tadalafil (or sildenafil). Papers 8 and 10 explicitly reference the known or reported association between PDE5 inhibitors and NAION. The other retrieved papers focus on semaglutide and GLP-1 RAs, which are tangential to PDE5 inhibitors.

Evidence for · 2
Flavone-C-glycosides from <i>Cassia auriculata</i> L. as possible inhibitors of phosphodiesterase-5 (PDE5): <i>in vitro</i>, molecular docking and molecular dynamics studies.
2026
Get citation
A, G. A., VM, H. P., K, B., S, B., R, J., R, K., SB, S., Y, N., & A, K. (2026). Flavone-C-glycosides from <i>Cassia auriculata</i> L. as possible inhibitors of phosphodiesterase-5 (PDE5): <i>in vitro</i>, molecular docking and molecular dynamics studies.. doi.org. https://doi.org/10.1080/07391102.2024.2431659

See more details
More for · 1
Sildenafil-Associated Anterior Ischemic Optic Neuropathy with Optic Nerve Enhancement in Brain Magnetic Resonance Imaging and Pleocytosis in Cerebrospinal Fluid: A Case Report.
2026
Get citation
G, M., N, A. K., S, M., & M, H. (2026). Sildenafil-Associated Anterior Ischemic Optic Neuropathy with Optic Nerve Enhancement in Brain Magnetic Resonance Imaging and Pleocytosis in Cerebrospinal Fluid: A Case Report.. doi.org. https://doi.org/10.1159/000552502

Receipt History
Anyone with this link can read the claim and its public receipt, including any personal information in that text. Open permanent receipt.
Check your own claim
Challenge the receipt
Requests are recorded for review. This does not start an automatic check or guarantee a response time.

See the evidence timeline

Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.

This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work