Mutations in the rhodopsin gene are a molecular pathogenic cause of Retinitis pigmentosa.

Is it true that mutations in the rhodopsin gene are a molecular pathogenic cause of Retinitis pigmentosa?

Yes. Mutations in the rhodopsin (RHO) gene are well-established molecular causes of retinitis pigmentosa, driving photoreceptor degeneration through mechanisms such as protein misfolding, endocytic stress, and mitochondrial dysfunction.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked 4 Oct 2026

C, H., X, S., T, Z., J, L., T, Z., Z, C., Y, W., Y, Z., S, W., Y, J., Y, W., H, C., J, S., T, L., J, Z., H, J., X, W., X, L., J, C., B, Y., & X, S. (2026). Enhanced Endocytosis and Mitochondrial Stress Underlie Severe Retinitis Pigmentosa With RHO P347L Mutant.. doi.org. https://doi.org/10.1167/iovs.67.8.23

SP, d. F. C., M, F., AL, M. N., ALB, A., RR, A., V, M., LAC, D. M., & MB, N. (2025). Genetic and clinical characterization of suspected retinitis pigmentosa in a cohort of Brazilian patients.. europepmc.org. https://europepmc.org/article/MED/41867384

M, T. & PS, P. (2026). Cone Opsins and Inherited Retinal Disease.. doi.org. https://doi.org/10.3390/cells15121098