trustmebro.to/r/…
✓ checked
trust me, bro:
here is the receipt.
the claim

Mutant variants of the TDP-43 protein are causative for amyotrophic lateral sclerosis.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Mutant variants of the TDP-43 protein are causative for amyotrophic lateral sclerosis?

Yes. Mutant variants of the TDP-43 protein are recognized as causative factors in amyotrophic lateral sclerosis, contributing to disease pathogenesis through both toxic gain-of-function and loss-of-function mechanisms.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently supports the claim that TARDBP/TDP-43 mutations are causative for familial and related forms of amyotrophic lateral sclerosis, driving both aggregation pathology and neurodegeneration.

Evidence for · 2
Human iPSC-derived motor neurons as a platform for elucidating TDP-43-related amyotrophic lateral sclerosis pathogenesis: a mini review.
2026
Heterozygous mutations in the TARDBP gene (encoding TDP-43) are established causes of familial amyotrophic lateral sclerosis (ALS10).
Get citation
S, Y., Y, I., & M, K. (2026). Human iPSC-derived motor neurons as a platform for elucidating TDP-43-related amyotrophic lateral sclerosis pathogenesis: a mini review.. doi.org. https://doi.org/10.3389/fnmol.2026.1864964

See more details
More for · 1
Pathogenicity Classification of <i>TARDBP</i> Variants of Uncertain Significance: An Integrative Clinical Characterization and Functional Validation.
2026
TARDBP is a major causative gene of amyotrophic lateral sclerosis, where mutant variants drive disease through gain-of-toxicity and loss-of-function mechanisms.
Get citation
CS, Y., Y, M., JL, X., XY, L., YT, L., TX, W., HF, X., SM, Z., ZY, W., & HF, L. (2026). Pathogenicity Classification of <i>TARDBP</i> Variants of Uncertain Significance: An Integrative Clinical Characterization and Functional Validation.. doi.org. https://doi.org/10.3390/cells15141232

What does the evidence say?

The retrieved literature consistently supports the claim that TARDBP/TDP-43 mutations are causative for familial and related forms of amyotrophic lateral sclerosis, driving both aggregation pathology and neurodegeneration.

Receipt History
Anyone with this link can read the claim and its public receipt, including any personal information in that text. Open permanent receipt.
Check your own claim
Challenge the receipt
Requests are recorded for review. This does not start an automatic check or guarantee a response time.

See the evidence timeline

Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.

This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work