Molecular properties determine the systemic absorption of topical medications
the verdict
SUPPORTED
the evidence backs this
confidence 95/100
Molecular properties such as size, lipophilicity, and weight directly dictate how effectively topical medications can penetrate the skin barrier and enter systemic circulation.
Evidence for · 4
The 500 Dalton rule for the skin penetration of chemical compounds and drugs
2000 · cited by 1,430
The 500 Dalton rule demonstrates how molecular weight and properties restrict skin penetration and absorption of compounds.
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More for · 3
Topical pyridostigmine for ocular myasthenia gravis: a translational hypothesis.
2026 · cited by 0
Discusses how the small, hydrophilic molecular properties of pyridostigmine favor specific permeability profiles like conjunctival penetration.
Engineering skin microphysiological systems for transdermal drug screening based on strategic model selection and quantitative prediction roadmaps.
2026 · cited by 0
Examines physiological determinants and physicochemical properties governing transdermal absorption and transport.
Nanotechnologies for Skin Drug Delivery: Polymeric, Bio-Based, and Hybrid Nanocarriers with Clinical and Translational Perspectives.
2026 · cited by 0
Notes that extent of systemic delivery varies widely depending on drug physicochemical properties and molecular weight.