Migratory aptitude in the Baeyer-Villiger reaction follows electronic and steric factors
the verdict
SUPPORTED
the evidence backs this
confidence 84/100
Migratory aptitude in the Baeyer-Villiger reaction is fundamentally dictated by electronic and steric factors, such as the migrating group's ability to stabilize positive charge and the relief of steric strain, though specialized enzymes can sometimes override these classical trends.
Evidence for · 4
Overriding Traditional Electronic Effects in Biocatalytic Baeyer-Villiger Reactions by Directed Evolution.
2018 · cited by 27
This study discusses how electronic and steric factors govern Baeyer-Villiger regioselectivity, even though enzymatic directed evolution can sometimes override these traditional effects.
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More for · 3
Steric Effects in the Baeyer–Villiger Reaction of Simple Ketones
1973 · cited by 19
Early foundational work specifically details how steric and electronic effects dictate migratory aptitude and selectivity in the Baeyer-Villiger reaction of simple ketones.
Solution Structures and Molecular Associations of a Peptide-Based Catalyst for the Stereoselective Baeyer-Villiger Oxidation
2016 · cited by 16
This paper notes a peptide-based catalyst's facility to control both enantioselectivity and migratory aptitude in the Baeyer-Villiger oxidation, confirming the operation of these underlying factors.
Conformational and steric effects on regioselectivity in the Baeyer–Villiger reaction
1984 · cited by 9
This research highlights how steric effects and the relief of non-bonded interactions determine regioselectivity and migratory preference during the Baeyer-Villiger reaction.