Microchimerism can occur during pregnancy due to two-way cell trafficking between a mother and her foetus.

the verdict

SUPPORTED

the evidence backs this

Recorded sources

3 sources for · 0 against

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Is it true that Microchimerism can occur during pregnancy due to two-way cell trafficking between a mother and her foetus?

Yes. Microchimerism is well-documented to occur during pregnancy as a result of bidirectional cell trafficking between the mother and the fetus, with cells persisting in various tissues for decades.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked 4 Oct 2026

The analysis

The retrieved papers consistently support the scientific consensus that microchimerism arises from bidirectional cell trafficking (both feto-maternal and maternal-fetal) across the placenta during pregnancy. No papers refute this premise.

Evidence for · 3

Fetal microchimerism and maternal health during and after pregnancy

2008

This study explains that bidirectional cell trafficking occurs during normal pregnancy, allowing fetal cells to cross into maternal circulation and persist as microchimeric cells.

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O'Donoghue, K. (2008). Fetal microchimerism and maternal health during and after pregnancy. doi.org. https://doi.org/10.1258/om.2008.080008

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More for · 2

Chimerism and immunological tolerance in solid organ transplantation.

2025

This review highlights that naturally occurring chimerism results from bidirectional transplacental cell trafficking during pregnancy.

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B, O., AD, G., D, H., J, O., W, J., & DE, Z. (2025). Chimerism and immunological tolerance in solid organ transplantation.. doi.org. https://doi.org/10.1007/s00281-025-01052-x

Feto-Maternal Microchimerism and the Brain: Mechanisms, Neurological Implications, and Translational Perspectives.

2026

This paper notes that microchimerism in the brain and other tissues is a common phenomenon driven by cells crossing between mother and fetus during pregnancy.

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NO, A. (2026). Feto-Maternal Microchimerism and the Brain: Mechanisms, Neurological Implications, and Translational Perspectives.. doi.org. https://doi.org/10.1111/aji.70317

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