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Melatonin is produced by the pineal gland.
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SUPPORTED
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12 sources for · 0 against
Is it true that melatonin is produced by the pineal gland?
Yes. Multiple reference and peer-reviewed sources state that melatonin is produced (synthesized and secreted) by the pineal gland, including encyclopedia, clinical, and textbook entries. A few research items confirm pineal melatonin production in specific species or contexts.
Verdict: SUPPORTED · 12 sources for, 0 against · Last checked
Evidence for · 12
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Melatonin. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Melatonin
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More for · 11
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Pineal gland. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Pineal_gland
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Pineal Gland: What It Is, Function & Disorders. (n.d.). my.clevelandclinic.org. https://my.clevelandclinic.org/health/body/23334-pineal-gland
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HPLC validation of a circadian melatonin rhythm in the pineal gland of inbred mice. (n.d.). cir.nii.ac.jp. https://doi.org/10.1111/j.1600-079x.1996.tb00249.x
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Human Phenotype Ontology: Abnormality of the pineal gland. (n.d.). purl.obolibrary.org. http://purl.obolibrary.org/obo/HP_0012680
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LibreTexts: 18.21%3A The Pancreas Pineal Gland and Gonads. (n.d.). bio.libretexts.org. https://bio.libretexts.org/Courses/Lumen_Learning/Biology_for_Majors_II_(Lumen)/18%3A_Module_15-_The_Endocrine_System/18.21%3A_The_Pancreas_Pineal_Gland_and_Gonads
Melatonin-Secreting Pineal Gland: A Novel Tissue Source for Neural Transplantation Therapy in Stroke
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Melatonin-Secreting Pineal Gland: A Novel Tissue Source for Neural Transplantation Therapy in Stroke. (n.d.). cir.nii.ac.jp. https://doi.org/10.3727/000000003108746786
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Daily oscillation in melatonin synthesis in the Turkey pineal gland and retina: diurnal and circadian rhythms. (2006). hal.science. https://hal.science/hal-00093412v1
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G, N., G, N., & AI, A. (2026). Physiological relevance of autocrine melatonin signaling in pineal and extrapineal sites: a systematic review.. doi.org. https://doi.org/10.1152/function.101.2025
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Paditz, E. (2024). Postnatal Development of the Circadian Rhythmicity of Human Pineal Melatonin Synthesis and Secretion (Systematic Review). doi.org. https://doi.org/10.3390/children11101197
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Leonardi, P. (2004). The Ultimate Study Guide For Biology: Key Review Questions and Answers with Explanations (Topics: Kingdom Animalia, Organization of the Animal Body, Animal Form and Function, Animal Reproduction, Development and Behavior) Volume 3. archive.org. https://archive.org/details/ultimatestudygui0003patr
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Melatonin Supplementation in Beta-Blocker -Induced Insomnia: A Literature Review. (2015). doi.org. https://doi.org/10.52403/ijrr.20251217
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