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Magnesium ions block the NMDA glutamate receptor channel in neurons at resting membrane potential, and the block is relieved when the neuron depolarizes.
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SUPPORTED
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10 sources for · 0 against
Is it true that magnesium ions block the NMDA glutamate receptor channel in neurons at resting membrane potential, and the block is relieved when the neuron depolarizes?
Yes. A reference article states directly that the NMDA receptor channel is blocked by Mg2+ at resting membrane potential and that depolarizing the postsynaptic cell removes the block. Several peer-reviewed papers independently confirm the voltage-dependent block by extracellular magnesium, though they examine its kinetics, molecular site, or pharmacology rather than the basic resting/depolarized mechanism.
Verdict: SUPPORTED · 10 sources for, 0 against · Last checked
Evidence for · 10
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NMDA receptor. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/NMDA_receptor
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More for · 9
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Benveniste, M. & Mayer, M. L. (1995). Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9‐aminoacridine.. doi.org. https://doi.org/10.1113/jphysiol.1995.sp020591
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Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations. (2012). doi.org. https://doi.org/10.1016/j.neuropharm.2011.12.029
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Vargas-Caballero, M. & Robinson, H. P. C. (2004). Fast and Slow Voltage-Dependent Dynamics of Magnesium Block in the NMDA Receptor: The Asymmetric Trapping Block Model. doi.org. https://doi.org/10.1523/jneurosci.1380-04.2004
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Developmental Changes in NMDA-Induced Intrinsic Optical Signals in the Hippocampal Dentate Gyrus of Children with Medically Intractable Seizures. (1999). doi.org. https://doi.org/10.1159/000017401
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A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux. (2001). doi.org. https://doi.org/10.1038/88404
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Control by Asparagine Residues of Calcium Permeability and Magnesium Blockade in the NMDA Receptor. (n.d.). cir.nii.ac.jp. https://doi.org/10.1126/science.1382314
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Electrophysiological and Pharmacological Characteristics of Ionotropic Glutamate Receptors in Medial Vestibular Nucleus Neurons: A Whole Cell Patch Clamp Study in Acutely Dissociated Neurons.. (n.d.). cir.nii.ac.jp. https://doi.org/10.1254/jjp.72.335
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[Role of magnesium ions on the regulation of NMDA receptor--a pharmacopathology of memantine].. (n.d.). cir.nii.ac.jp. https://cir.nii.ac.jp/crid/1871995343674313472
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Identification by mutagenesis of a Mg2+ -block site of the NMDA receptor channel. (n.d.). cir.nii.ac.jp. https://doi.org/10.1038/358673a0
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