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the claim

LSD causes the brain to release serotonin from nerve cells.

the verdict
INSUFFICIENT LEANING
Recorded sources
0 sources for · 2 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that LSD causes the brain to release serotonin from nerve cells?

Unclear. Two older studies bear on the claim only partially and point the other way: one reports that LSD inhibited electrically stimulated serotonin release from rat brain slices, and another proposes that LSD blocks presynaptic serotonin reuptake in the Limulus eye rather than causing release. Neither settles the general claim about LSD causing serotonin release from nerve cells.

Verdict: PARTIAL LEAN · 0 sources for, 2 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence against · 2
Serotonin Release from Brain Slices by Electrical Stimulation: Regional Differences and Effect of LSD
1967
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Chase, T. N., Breese, G. R., & Kopin, I. J. (1967). Serotonin Release from Brain Slices by Electrical Stimulation: Regional Differences and Effect of LSD. doi.org. https://doi.org/10.1126/science.157.3795.1461

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More against · 1
Presynaptic uptake blockade hypothesis for LSD action at the lateral inhibitory synapse in Limulus
1983
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Kass, L., Hartline, P. H., & Adolph, A. (1983). Presynaptic uptake blockade hypothesis for LSD action at the lateral inhibitory synapse in Limulus. doi.org. https://doi.org/10.1085/jgp.82.2.245

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