trustmebro.to/r/…
✓ checked
trust me, bro:
here is the receipt.
the claim

Long-term melatonin supplementation increases the risk of heart disease.

the verdict
CONTESTED PARTIAL
Recorded sources
1 source for · 7 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that long-term melatonin supplementation increases the risk of heart disease?

Partly. One letter cites observational data linking prolonged melatonin use (≥1 year) to higher heart failure incidence, hospitalization and mortality, while a 2025 meta-analysis of 63 RCTs and several reviews report melatonin improves cardiometabolic risk factors or shows no adverse cardiac effects. The evidence is partial on both sides and does not settle whether long-term melatonin supplementation increases heart disease risk.

Verdict: CONTESTED PARTIAL · 1 source for, 7 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 1
Letter to Editor “Melatonin as a Novel Drug to Improve Cardiac Function and Quality of Life in Heart Failure Patients: A Systematic Review and Meta‐Analysis” -
Get citation
Letter to Editor “Melatonin as a Novel Drug to Improve Cardiac Function and Quality of Life in Heart Failure Patients: A Systematic Review and Meta‐Analysis” - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1002/clc.70325

Evidence against · 7
Melatonin Supplementation in Children: A Narrative Review of Indications, Safety, and Potential Long-Term Effects
2020
Get citation
Hydzik, H. (2020). Melatonin Supplementation in Children: A Narrative Review of Indications, Safety, and Potential Long-Term Effects. doi.org. https://doi.org/10.14200/jrm.2020.0103

See more details
More against · 6
Effectiveness of melatonin supplementation for improving sleep quality and disease severity in children with atopic dermatitis: a systematic review and meta-analysis.
2025
Get citation
F, A., DY, A., RF, A., AH, A., EA, S., ST, S., RO, K., RA, A., RH, J., W, A., BH, A., RE, M., SS, A., NS, A., & AK, B. (2025). Effectiveness of melatonin supplementation for improving sleep quality and disease severity in children with atopic dermatitis: a systematic review and meta-analysis.. doi.org. https://doi.org/10.3389/fmed.2025.1718859

Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.
2025
Get citation
S, M., D, A., M, E., N, A., M, Y., P, S. P., M, M., SA, M., I, A., Y, E., M, M., O, A., K, S., & RJ, R. (2025). Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.. doi.org. https://doi.org/10.3390/nu18010134

Effects of Melatonin Supplementation on the Aortic Wall in a Diet-Induced Obesity Rat Model
2023
Get citation
Effects of Melatonin Supplementation on the Aortic Wall in a Diet-Induced Obesity Rat Model. (2023). doi.org. https://doi.org/10.7759/cureus.33333

Synergistic effects of intradialytic concurrent training and melatonin supplementation on immune cell adaptations in hemodialysis patients
2026
Get citation
Marzougui, H., Marzougui, H., Hachicha, H., Hachicha, H., Maaloul, R., & Maaloul, R. (2026). Synergistic effects of intradialytic concurrent training and melatonin supplementation on immune cell adaptations in hemodialysis patients. doi.org. https://doi.org/10.3389/fphar.2026.1880592

Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk.
2026
Get citation
CN, H. & YL, T. (2026). Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk.. doi.org. https://doi.org/10.3390/ijms27052390

The Effect of Long‐term Dietary Supplementation with Antioxidants a
Get citation
The Effect of Long‐term Dietary Supplementation with Antioxidants a. (n.d.). cir.nii.ac.jp. https://doi.org/10.1111/j.1749-6632.1998.tb09915.x

Receipt History
Anyone with this link can read the claim and its public receipt, including any personal information in that text. Open permanent receipt.
Check your own claim
Challenge the receipt
Requests are recorded for review. This does not start an automatic check or guarantee a response time.

Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.

This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work