Ketamine produces antidepressant effects within hours in people with treatment-resistant depression.

the verdict

INSUFFICIENT LEANING

Recorded sources

6 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Ketamine produces antidepressant effects within hours in people with treatment-resistant depression?

Unclear. Several peer-reviewed reviews and papers state that ketamine produces rapid antidepressant effects in treatment-resistant depression, but most are background statements or cover only adolescents, and none is a primary trial settling the general claim at full strength.

Verdict: PARTIAL LEAN · 6 sources for, 0 against · Last checked 2 Oct 2026

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 6

Ketamine for Treatment-Resistant Depression in Adolescents: Hope or Risk?

2026

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Pająk, J., Kamosińska, A., Sławatyniec, O., Sobieraj, W., Łuniewska, W., & Modrzyk, M. (2026). Ketamine for Treatment-Resistant Depression in Adolescents: Hope or Risk?. apcz.umk.pl. https://apcz.umk.pl/JEHS/article/view/74058

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More for · 5

Ketamine for Treatment-Resistant Depression in Adolescents: Hope or Risk?

2026

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Kamosińska, A., Pająk, J., Sławatyniec, O., Sobieraj, W., Łuniewska, W., & Modrzyk, M. (2026). Ketamine for Treatment-Resistant Depression in Adolescents: Hope or Risk?. doi.org. https://doi.org/10.12775/jehs.2026.95.73956

The Montreal model of ketamine-therapy for alcohol use disorder and comorbid treatment-resistant depression: protocol for a feasibility trial

2026

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Jutras-Aswad, D., Rizkallah, E., Lembke, A., McAnulty, C., Lavoie, P., & Cyr, S. (2026). The Montreal model of ketamine-therapy for alcohol use disorder and comorbid treatment-resistant depression: protocol for a feasibility trial. doi.org. https://doi.org/10.1136/bmjopen-2026-116969

TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats

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TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats. (n.d.). cir.nii.ac.jp. https://doi.org/10.1016/j.pbb.2021.173289

Comparative EEG analysis of the effects of ketamine enantiomers and metabolites in rhesus macaques

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Comparative EEG analysis of the effects of ketamine enantiomers and metabolites in rhesus macaques. (n.d.). cir.nii.ac.jp. https://doi.org/10.1152/jn.00203.2025

ケタミンの即効性抗うつ作用における前頭前野VEGFシグナルの役割

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ケタミンの即効性抗うつ作用における前頭前野VEGFシグナルの役割. (n.d.). cir.nii.ac.jp. https://doi.org/10.1254/jpssuppl.93.0_3-s30-3

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