Intestinal gas causes visceral pain through bowel distension and hypersensitivity
the verdict
SUPPORTED
the evidence backs this
confidence 90/100
Intestinal gas and bowel distension play a key role in triggering visceral pain, particularly in individuals with underlying visceral hypersensitivity such as those with irritable bowel syndrome.
Evidence for · 3
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome
2016 · cited by 290
Paper [3] demonstrates that carbohydrate-related symptoms in irritable bowel syndrome correlate with intraluminal gas and colonic sensitivity to distension.
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More for · 2
An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome
2001 · cited by 210
Paper [4] shows that patients with irritable bowel syndrome exhibit visceral hypersensitivity characterized by lowered thresholds to gas and balloon distension.
Precision Lactobacillus reuteri therapy attenuates luminal distension-associated visceral hypersensitivity by inducing peripheral opioid receptors in the colon
2020 · cited by 17
Paper [6] establishes that luminal distension directly induces visceral hypersensitivity in bowel disorders.