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the claim

In most populations, the peak incidence of acute lymphocytic leukaemia occurs at ages 1-4.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that in most populations, the peak incidence of acute lymphocytic leukaemia occurs at ages 1-4?

Yes. Evidence from epidemiological studies confirms that the peak incidence of acute lymphoblastic leukaemia occurs in early childhood, typically between the ages of 1 and 5 years.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked

The analysis

The retrieved papers consistently confirm that acute lymphoblastic leukemia (ALL) predominantly affects young children, with the characteristic peak incidence occurring between ages 1 and 5 (frequently cited as ages 2-4 or toddler/preschool age). Multiple studies support this well-established epidemiological fact, and no papers refute it.

Evidence for · 4
Clinical outcomes in pediatric acute lymphoblastic leukemia: a retrospective cohort study from a tertiary center in Indonesia.
2026
Noting that most pediatric acute lymphoblastic leukemia patients fall within the 1-10 age range, consistent with early childhood peaks.
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DP, S., DR, A., RM, I., & E, R. (2026). Clinical outcomes in pediatric acute lymphoblastic leukemia: a retrospective cohort study from a tertiary center in Indonesia.. doi.org. https://doi.org/10.3389/fped.2026.1830355

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More for · 3
The age incidence of childhood B-cell precursor acute lymphoblastic leukemia in Mexico City.
2008
Observing that the peak age for acute lymphoblastic leukemia occurs between 2 and 3 years.
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Bernaldez-Rios, R., Ortega-Alvarez, M. C., Perez-Saldivar, M. L., Alatoma-Medina, N. E., Campo-Martinez, M. d. L. A. D., Rodriguez-Zepeda, M. D. C., Montero-Ponce, I., Franco-Ornelas, S., Fernandez-Castillo, G., Nuñez-Villegas, N. N., Taboada-Flores, M. A., Flores-Lujano, J., Argüelles-Sanchez, M. E., Juarez-Ocaña, S., Fajardo-Gutierrez, A., & Mejia-Arangure, J. M. (2008). The age incidence of childhood B-cell precursor acute lymphoblastic leukemia in Mexico City.. doi.org. https://doi.org/10.1097/MPH.0b013e318162bcdc

Temporal trend and spatial distribution of acute lymphoblastic leukemia in Iranian children during 2006-2014: a mixed ecological study.
2020
Reporting that the peak incidence of acute lymphoblastic leukemia is observed among children aged 2 to 5 years.
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Pordanjani, S. R., Kavousi, A., Mirbagheri, B., Shahsavani, A., & Etemad, K. (2020). Temporal trend and spatial distribution of acute lymphoblastic leukemia in Iranian children during 2006-2014: a mixed ecological study.. doi.org. https://doi.org/10.4178/epih.e2020057

Prognostic impact of age in children and adolescents with acute lymphoblastic leukemia: data from the trials ALL-BFM 86, 90, and 95.
2005
Stating that the incidence peak of precursor B-cell acute lymphoblastic leukemia occurs during toddler and preschool years.
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Möricke, A., Zimmermann, M., Reiter, A., Gadner, H., Odenwald, E., Harbott, J., Ludwig, W., Riehm, H., & Schrappe, M. (2005). Prognostic impact of age in children and adolescents with acute lymphoblastic leukemia: data from the trials ALL-BFM 86, 90, and 95.. doi.org. https://doi.org/10.1055/s-2005-872515

What does the evidence say?

The retrieved papers consistently confirm that acute lymphoblastic leukemia (ALL) predominantly affects young children, with the characteristic peak incidence occurring between ages 1 and 5 (frequently cited as ages 2-4 or toddler/preschool age). Multiple studies support this well-established epidemiological fact, and no papers refute it.

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