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the claim
In 2025 the European Medicines Agency's safety committee concluded that non-arteritic anterior ischemic optic neuropathy (NAION) is a very rare side effect of semaglutide.
the verdict
SUPPORTED
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Recorded sources
3 sources for · 2 against
Is it true that in 2025 the European Medicines Agency's safety committee concluded that non-arteritic anterior ischemic optic neuropathy (NAION) is a very rare side effect of semaglutide?
Yes. The European Medicines Agency's own 6 June 2025 announcement states that its safety committee (PRAC) concluded NAION is a very rare side effect of semaglutide medicines. A commentary's reference list also cites that EMA conclusion, while later reviews dispute causality but do not address what PRAC concluded.
Verdict: SUPPORTED · 3 sources for, 2 against · Last checked
Evidence for · 3
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Emerging risk of non-arteritic anterior ischemic optic neuropathy (NAION) with semaglutide: a safety alert for clinicians - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1097/MS9.0000000000004914
Evidence against · 2
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N, E. & O, B. (2026). Semaglutide and Non-arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Narrative Synthesis.. doi.org. https://doi.org/10.1016/j.aed.2026.01.001
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More for · 2
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PRAC concludes eye condition NAION is a very rare side effect of semaglutide medicines Ozempic, Rybelsus and Wegovy | European Medicines Agency (EMA). (n.d.). ema.europa.eu. https://www.ema.europa.eu/en/news/prac-concludes-eye-condition-naion-very-rare-side-effect-semaglutide-medicines-ozempic-rybelsus-wegovy
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Semaglutide (Wegovy, Ozempic and Rybelsus): risk of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) - GOV.UKGOV.UK. (n.d.). gov.uk. https://www.gov.uk/drug-safety-update/semaglutide-wegovy-ozempic-and-rybelsus-risk-of-non-arteritic-anterior-ischemic-optic-neuropathy-naion
More against · 1
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FA, A., MA, A., YB, A., AK, A., AA, A., MA, A., M, A., SA, A., SM, A., & AY, A. (2026). Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP-1 Receptor Agonists.. doi.org. https://doi.org/10.1002/acn3.70406
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