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In 2025 the European Medicines Agency's safety committee concluded that non-arteritic anterior ischemic optic neuropathy (NAION) is a very rare side effect of semaglutide.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 2 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that in 2025 the European Medicines Agency's safety committee concluded that non-arteritic anterior ischemic optic neuropathy (NAION) is a very rare side effect of semaglutide?

Yes. The European Medicines Agency's own 6 June 2025 announcement states that its safety committee (PRAC) concluded NAION is a very rare side effect of semaglutide medicines. A commentary's reference list also cites that EMA conclusion, while later reviews dispute causality but do not address what PRAC concluded.

Verdict: SUPPORTED · 3 sources for, 2 against · Last checked

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Evidence for · 3
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Emerging risk of non-arteritic anterior ischemic optic neuropathy (NAION) with semaglutide: a safety alert for clinicians - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1097/MS9.0000000000004914

Evidence against · 2
2026
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N, E. & O, B. (2026). Semaglutide and Non-arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Narrative Synthesis.. doi.org. https://doi.org/10.1016/j.aed.2026.01.001

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More for · 2
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PRAC concludes eye condition NAION is a very rare side effect of semaglutide medicines Ozempic, Rybelsus and Wegovy | European Medicines Agency (EMA). (n.d.). ema.europa.eu. https://www.ema.europa.eu/en/news/prac-concludes-eye-condition-naion-very-rare-side-effect-semaglutide-medicines-ozempic-rybelsus-wegovy

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Semaglutide (Wegovy, Ozempic and Rybelsus): risk of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) - GOV.UKGOV.UK. (n.d.). gov.uk. https://www.gov.uk/drug-safety-update/semaglutide-wegovy-ozempic-and-rybelsus-risk-of-non-arteritic-anterior-ischemic-optic-neuropathy-naion

More against · 1
2026
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FA, A., MA, A., YB, A., AK, A., AA, A., MA, A., M, A., SA, A., SM, A., & AY, A. (2026). Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP-1 Receptor Agonists.. doi.org. https://doi.org/10.1002/acn3.70406

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