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the claim
Hypothyroidism raises blood cholesterol levels, particularly LDL cholesterol.
the verdict
INSUFFICIENT LEANING
Recorded sources
5 sources for · 0 against
Is it true that hypothyroidism raises blood cholesterol levels, particularly LDL cholesterol?
Unclear. Several sources link hypothyroidism to abnormal blood lipid levels and treat LDL and total cholesterol as markers of thyroid hormone signaling, but none directly quantifies the rise in LDL caused by hypothyroidism; the strongest item covers only subclinical hypothyroidism and calls the lipid benefits hypothesis-generating.
Verdict: PARTIAL LEAN · 5 sources for, 0 against · Last checked
Evidence for · 5
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A., M. E., B., R. K., & H., M. C. (2018). Data from: Systemic thyroid hormone status during levothyroxine therapy in hypothyroidism: a systematic review and meta-analysis. zenodo.org. https://doi.org/10.5061/dryad.7ph3219
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More for · 4
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MA, H. E., MA, A., Y, O. A. A., IE, M., MA, K., EA, E., H, N., & A, A. (2026). Cardiometabolic Outcomes and Levothyroxine Treatment Effects in Subclinical Hypothyroidism: A Systematic Review.. doi.org. https://doi.org/10.7759/cureus.114468
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Effects of Thyroid Dysfunction on Lipid Profile - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.2174/1874192401105010076
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Clara, L. (2025). Enzymes in Blood Lipid Metabolism. zenodo.org. https://doi.org/10.5281/zenodo.14650065
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Clara, L. (2023). Enzymes in Blood Lipid Metabolism. zenodo.org. https://doi.org/10.5281/zenodo.8288921
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