trustmebro.to/r/…
✓ checked
trust me, bro:
here is the receipt.
the claim

Humans convert folic acid to its active form slowly, so unmetabolised folic acid can appear in the bloodstream after high intakes.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that humans convert folic acid to its active form slowly, so unmetabolised folic acid can appear in the bloodstream after high intakes?

Yes. A peer-reviewed study of human liver reports that dihydrofolate reductase converts folic acid extremely slowly and notes this is consistent with reports of unmetabolised folic acid in plasma. Other sources confirm folic acid requires hepatic conversion and that unmetabolised folic acid circulates in blood after high intakes.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 5
Circulating Unmetabolized Folic Acid: Relationship to Folate Status and Effect of Supplementation -
Get citation
Circulating Unmetabolized Folic Acid: Relationship to Folate Status and Effect of Supplementation - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1155/2012/485179

See more details
More for · 4
The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake
Get citation
The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. (n.d.). cir.nii.ac.jp. https://doi.org/10.1073/pnas.0902072106

Folic Acid Safety, Interactions, and Health Outcomes | Folic Acid | CDC
Get citation
Folic Acid Safety, Interactions, and Health Outcomes | Folic Acid | CDC. (n.d.). cdc.gov. https://www.cdc.gov/folic-acid/about/safety.html

Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy.
2020
Get citation
Ferrazzi, E., Tiso, G., & Martino, D. D. (2020). Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy.. doi.org. https://doi.org/10.1016/j.ejogrb.2020.06.012

Benefits of folate status correction using metafolin-contained vitamin-mineral complex
2018
Get citation
Ших, Е. В. & Махова, А. А. (2018). Benefits of folate status correction using metafolin-contained vitamin-mineral complex. zenodo.org. https://doi.org/10.18370/2309-4117.2018.40.88-92

Receipt History
Anyone with this link can read the claim and its public receipt, including any personal information in that text. Open permanent receipt.
Check your own claim
Challenge the receipt
Requests are recorded for review. This does not start an automatic check or guarantee a response time.

Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.

This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work