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the claim

HIV uses the CD4 receptor to enter T cells and reproduce.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that HIV uses the CD4 receptor to enter T cells and reproduce?

Yes. The scientific literature consistently supports the fundamental mechanism that HIV utilizes the CD4 receptor to facilitate viral entry and subsequent replication in T cells.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

The analysis

All provided papers corroborate that CD4 acts as the primary receptor for HIV entry and infection in T cells, which fully supports the claim.

Evidence for · 3
Mobility of the Human Immunodeficiency Virus (HIV) Receptor CD4 and Coreceptor CCR5 in Living Cells: Implications for HIV Fusion and Entry Events
2004
Discusses CD4 as the receptor for human immunodeficiency virus fusion and entry.
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Steffens, C. M. & Hope, T. J. (2004). Mobility of the Human Immunodeficiency Virus (HIV) Receptor CD4 and Coreceptor CCR5 in Living Cells: Implications for HIV Fusion and Entry Events. doi.org. https://doi.org/10.1128/jvi.78.17.9573-9578.2004

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More for · 2
Penetration of CD4 T cells by HIV-1. The CD4 receptor does not internalize with HIV, and CD4-related signal transduction events are not required for entry
1991
Confirms that receptor binding of HIV to the CD4 molecule is required for infection of T cells.
Get citation
Orloff, G. M., Orloff, S. L., Kennedy, M. S., Maddon, P. J., & McDougal, J. S. (1991). Penetration of CD4 T cells by HIV-1. The CD4 receptor does not internalize with HIV, and CD4-related signal transduction events are not required for entry. doi.org. https://doi.org/10.4049/jimmunol.146.8.2578

HIV-1 Hijacks HGF/c-MET Signaling to Promote Viral Entry and Replication in Primary CD4 <sup>+</sup> T Cells
2026
Shows that c-MET disruption reduces cell-surface expression of the HIV receptor CD4, restricting viral entry and replication in CD4+ T cells.
Get citation
Tripathi, S., Allen, M. M., & Wu, L. (2026). HIV-1 Hijacks HGF/c-MET Signaling to Promote Viral Entry and Replication in Primary CD4
                  <sup>+</sup>
                  T Cells. doi.org. https://doi.org/10.64898/2026.08.03.742552

What does the evidence say?

All provided papers corroborate that CD4 acts as the primary receptor for HIV entry and infection in T cells, which fully supports the claim.

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