Histone synthesis occurs concurrently with DNA replication during the S phase of the cell cycle.
the verdict
SUPPORTED
the evidence backs this
confidence 86/100
Multiple studies and foundational research confirm that histone synthesis and DNA replication are tightly coupled and occur concurrently during the S phase of the cell cycle to ensure proper chromatin assembly and genomic stability.
Evidence for · 7
The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells
2004 · cited by 63
Paper 2 demonstrates that human HBP/SLBP is essential for the coordinate synthesis of DNA and histone proteins during the cell cycle.
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More for · 6
Coupling of Histone and DNA Synthesis in the Somatic Cell Cycle
1982 · cited by 25
Paper 3 establishes a direct correlation between the rates of DNA and histone synthesis, showing they are coupled.
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability
2026 · cited by 6
Paper 5 details how histone gene expression and transcription condensates are precisely controlled and balanced with DNA replication across the S phase.
ANKHD1 is an S phase protein required for histone synthesis and DNA repair in multiple myeloma cells.
2020 · cited by 5
Paper 6 notes that histone synthesis occurs in parallel with DNA replication at the S phase.
Modelling Robust Feedback Control Mechanisms That Ensure Reliable Coordination of Histone Gene Expression with DNA Replication
2016 · cited by 4
Paper 7 models the robust feedback control mechanisms ensuring the reliable coordination of histone gene expression with DNA replication.
Coordination of DNA synthesis and histone gene expression during normal cell cycle progression and after DNA damage.
2004 · cited by 0
Paper 9 states that chromosomal DNA replication and histone synthesis are tightly coupled during the S phase of the eukaryotic cell division cycle.
PRMT5 activity sustains histone production to maintain genome integrity.
2025 · cited by 0
Paper 11 shows that PRMT5 activity is required to sustain histone transcription and histone protein synthesis during the S phase.